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Trials to evaluate drugs or devices used to treat chronic medical conditions that are published early in the chain of evidence often show an exaggerated treatment effect compared with subsequent trials

Early Studies Often Show Exaggerated Treatment Effect

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Findings based on assessment of trials evaluating drugs, devices to treat chronic medical conditions
For patients with chronic-phase chronic myeloid leukemia

Treatment-Free Remission Feasible After Nilotinib in CML

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For patients with chronic myeloid leukemia in chronic phase, TFR is feasible after second-line treatment
In women with type 2 diabetes

No Link Found for Metformin or Statins and Ovarian Cancer

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Findings based on a Finnish study involving a national cohort of women with type 2 diabetes
Understanding nonadherence in patients and encouraging a change in attitude toward patients and their medication can improve medication adherence

Understanding Rx Nonadherence Can Improve Adherence

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Changing attitudes toward patients and their medication adherence can improve adherence
Artificial intelligence

Artificial Intelligence May Help Prevent Physician Burnout

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Many potential uses for AI, including improving searches and documentation, selecting treatment
The antibiotic clarithromycin (brand name: Biaxin) may increase the long-term risk of heart problems and death in patients with heart disease

FDA Warns of Possible Heart Risks Linked to Clarithromycin

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Agency advising doctors to consider prescribing other antibiotics to patients with coronary heart disease
From 2004 to 2014

Private Insurance Coverage of Infused Chemo Varies by Setting

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Better reimbursement at hospital outpatient depts, even though drug-level costs lower in doctor's office
There have been small but significant reductions in the incidence and prevalence of benzodiazepine use in older adults in Canada

Benzodiazepine Use Declining in Older Adults

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Findings based on assessment of incidence, prevalence of use in three countries from 2010-2016
For critically ill adults at high risk of delirium

Haloperidol for Delirium in Critically Ill No Help for Survival

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Prophylactic haloperidol does not improve survival at 28 days compared with placebo in critically ill adults
For adults with major depressive disorder

21 Reviewed Antidepressants Top Placebo for Major Depression

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Agomelatine, amitriptyline, escitalopram are among most effective agents in head-to-head trials