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For castration-resistant prostate cancer

Low-Dose Abiraterone Acetate Noninferior for Prostate Cancer

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Low-dose AA with low-fat breakfast had greater effect on PSA; similar effect to standard dose
County-level economic and other social conditions explain the geographic disparities in overdose rates across the country

Geographic, Social Variances Tied to Higher Drug-Related Mortality

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Economic, social conditions, and family distress tied to higher drug mortality rates
Exposure to sodium valproate or a combination of antiepileptic drugs in utero is associated with worse attainment on national educational tests for 7-year-olds

Educational Attainment Down With In Utero Exposure to AEDs

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Exposure to sodium valproate, combo of antiepileptic drugs tied to worse attainment on national tests
Electronic health record usability may contribute to possible patient harm events

EHR Usability Contributes to Possible Patient Harm Events

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Usability challenges mainly occur during order placement and medication administration
Only about 50 percent of adults with familial hypercholesterolemia are on statin therapy

Only Half of Adults With Familial Hypercholesterolemia on Statins

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And, only 30.3 percent of patients with definite or probable FH on statins take high-intensity statin
Intravitreal anti-vascular endothelial growth factor treatment is not associated with increased risk of systemic adverse events for patients with neovascular age-related macular degeneration

Intravitreal Anti-VEGF Use Not Tied to Systemic Adverse Events

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Risk not up in neovascular age-related macular degeneration, diabetic macular edema

The Endocrine Society, March 17-20

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The Endocrine Society's 100th Annual Meeting and Expo The annual meeting of The Endocrine Society was held from March 17 to 20 in...
Nonsteroidal anti-inflammatory drug use is associated with increased risk of atrial fibrillation in a middle-aged Asian population

NSAID Use Linked to A-Fib Risk in Middle-Aged Asian Population

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Risk up with use of non-selective NSAIDs and combined use of selective, non-selective NSAIDs
For patients with previously untreated clear-cell advanced renal-cell carcinoma

Nivolumab Plus Ipilimumab Tops Sunitinib for Advanced Renal CA

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Overall survival, objective response higher than sunitinib for untreated clear-cell advanced RCC
For patients with secondary progressive multiple sclerosis

Siponimod Cuts Risk of Disability Progression in Multiple Sclerosis

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Reduction in 3-month confirmed disability progression in secondary progressive multiple sclerosis