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A first opioid lawsuit is targeting pharmacy benefit managers

First Opioid Lawsuit Targeting Pharmacy Benefit Managers

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First lawsuit mentions three largest PBMs; PBMs likely to be increasingly targeted in litigation
Heavy use of opiates among patients with inflammatory bowel diseases is tied to increased risk of premature all-cause death

Opiate Use Linked to Early Mortality in IBD Patients

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Heavy use in Crohn's, heavy or moderate use in ulcerative colitis tied to increased risk of death
Cancer survivors are more likely to be prescribed five or more unique medications

Polypharmacy More Likely for Cancer Survivors

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More cancer survivors prescribed five or more unique medications, including those with abuse potential
For patients with human epidermal growth factor receptor 2/neu-positive uterine serous carcinoma

New Drug Combo Ups Survival in HER2/neu Uterine Serous Cancer

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Adding intravenous trastuzumab to carboplatin-paclitaxel increased progression-free survival
For patients with chronic obstructive pulmonary disease

Triple Therapy Tied to Reduced Rate of COPD Exacerbations

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Benefits seen for triple therapy with fluticasone furoate, umeclidinium, and vilanterol
Messages relating to safe storage and disposal of prescription opioids are inconsistent and are often not included on package insert information

Opioid Packaging Often Lacks Info on Safe Storage, Disposal

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Instructions for safe disposal of unused opioid medications often inconsistent, infrequent, or absent
Use of short-acting calcium channel blockers is associated with increased risk of pancreatic cancer in postmenopausal women

Calcium Channel Blockers May Up Pancreatic Cancer Risk in Women

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Increased hazard ratios for pancreatic cancer among postmenopausal users of short-acting CCBs
The U.S. Preventive Services Task Force concludes that exercise interventions may be beneficial for preventing falls in older adults; however

USPSTF: Exercise Interventions Prevent Falls in Seniors

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Second recommendation statement finds evidence lacking for benefit of calcium, vitamin D, or both
The estimated annual cost of drug-related morbidity and mortality resulting from nonoptimized medication therapy is more than half a trillion dollars in the United States

Nonoptimized Drug Therapy Costs More Than $500 Billion Annually

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After initial Rx use, average cost of individual having treatment failure, new medical problem over $2,000
Pembrolizumab is associated with significantly longer recurrence-free survival than placebo as adjuvant therapy for high-risk stage III melanoma

Adjuvant Pembrolizumab Beneficial in Stage III Melanoma

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Pembrolizumab linked to significantly longer recurrence-free survival at 15-month follow-up