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The first biosimilar drug to Neulasta has been approved by the U.S. Food and Drug Administration. Fulphila (pegfilgrastim) is approved for patients with non-myeloid cancer who are receiving myelosuppressive chemotherapy and have symptoms of febrile neutropenia.

FDA OKs 1st Biosimilar to Prevent Chemo-Related Infections

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Fulphila, biosimilar to Neulasta, helps reduce risk of infection during cancer treatment
A recall of the opioid overdose antidote Naloxone was announced Monday. The U.S. Food and Drug Administration said the recall was triggered by the possibility of "loose particulate matter on the syringe plunger" that could pose a number of health risks

FDA: Opioid Antidote Naloxone Recalled

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Two lots of Naloxone recalled due to potential presence of particulate matter in syringe plunger
For women with hormone-receptor-positive

ASCO: Endocrine Tx Noninferior for HR+, HER2− Breast Cancer

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Similar efficacy for endocrine, chemoendocrine tx for women with midrange 21-gene recurrence score
The oxaliplatin

ASCO: mFOLFIRINOX Improves Survival in Pancreatic Cancer

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And, pre-op chemoradiotherapy linked to longer overall survival than immediate surgery
Liposomal bupivacaine use in patients undergoing total knee arthroplasty is not associated with clinically meaningful reductions in inpatient opioid use

Benefit of Liposomal Bupivacaine for Pain in TKA Questioned

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No clinically relevant reduction in inpatient opioid use, costs for patients undergoing total knee arthroplasty
Among an urban

Few High-Risk Mothers in Boston Took Folic Acid Before Pregnancy

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Group was mostly low-income, minority; one-third had too-low or too-high plasma folate levels
Biotin

Case Shows Biotin Can Interfere With Multiple Endocrine Tests

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48-year-old woman taking biotin had abnormal results for multiple tests, including total testosterone
For patients with programmed death ligand 1 (PD-L1)-expressing locally advanced or metastatic non-small-cell lung cancer

ASCO: Pembrolizumab Superior for Initial Tx of Advanced NSCLC

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Improved overall survival versus chemotherapy regardless of the PD-L1 tumor proportion score
No new or unexpected safety issues have been identified in association with diphtheria-tetanus-acellular pertussis vaccines in the United States

No New Adverse Events Reported for DTaP Vaccination

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Most frequently reported adverse events included injection site erythema and swelling, pyrexia
For patients with metastatic renal cell carcinoma classified as having intermediate or poor prognostic risk

ASCO: Sunitinib Alone Noninferior in Metastatic Renal Cell Cancer

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Sunitinib alone noninferior to nephrectomy plus sunitinib with respect to overall survival