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For chronic migraine

Meta-Analysis: Botulinum A Tops Placebo for Chronic Migraine

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Frequency of chronic migraines significantly reduced after three months; QoL improved
For women with provoked vulvodynia

Gabapentin Improves Sexual Function in Provoked Vulvodynia

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Sexual function improved for gabapentin vs. placebo, but still lower than among matched pain-free controls
For patients with chronic obstructive pulmonary disease hospitalization

Flu Vaccine Cuts Flu-Related Hospitalization in COPD Patients

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Flu-positive patients have higher crude mortality and critical illness versus flu-negative patients
An approach involving a combination of provider report and pharmacy refill data can improve identification of medication nonadherence among youth with chronic kidney disease

Multimethod Approach Improves ID of Med Nonadherence

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Use of provider report, medication possession ratio improved ID of nonadherence in youth with CKD
For patients with secondary progressive multiple sclerosis

Rituximab Beneficial in Secondary Progressive MS

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Treatment with rituximab linked to lower Expanded Disability Status Scale score, delayed progression
Prescribed opioids are associated with an increased risk for community-acquired pneumonia requiring hospitalization among persons with and without HIV

Rx Opioids Up Pneumonia Risk in Patients With, Without HIV

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Risk greatest with higher-dose opioids and opioids with immunosuppressive properties
The risks for therapy-related myelodysplastic syndrome or acute myeloid leukemia are elevated after chemotherapy use for solid tumors

Myelodysplastic Syndrome/AML Risk Increased After Chemo

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Since 2000, risks for therapy-related myelodysplastic syndrome, AML up after chemo for solid cancers
A rule with six criteria can determine whether patients can be safely discharged from the emergency department after a one-hour observation period following prehospital naloxone administration

Discharge One Hour After Naloxone for OD May Be Option

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New rule has sensitivity, specificity of 84.1, 62.1 percent for patients receiving prehospital naloxone
Use of the antiepileptic drug valproate during pregnancy is associated with an increased risk for attention-deficit/hyperactivity disorder among offspring

Prenatal Valproate Exposure Linked to Increased ADHD Risk

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Maternal use of other antiepileptic drugs not tied to increased ADHD risk
From 1999 to 2016

Pediatric Mortality Rate From Opioid Poisoning Rose 1999 to 2016

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Pediatric mortality rate increased from 0.22 to 0.81 per 100,000; rates highest for 15- to 19-year-olds