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In the latest evidence-based guideline from the American College of Chest Physicians

Guidelines Updated for Pulmonary Arterial Hypertension in Adults

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New evidence led to development of two new recommendations for combination therapy
Neoadjuvant administration of programmed cell death protein 1 blockade seems to enhance local and systemic antitumor immune response in glioblastoma

Neoadjuvant PD-1 Blockade Seems Effective in Glioblastoma

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Neoadjuvant pembrolizumab with adjuvant therapy after surgery linked to extended overall survival
For children with acute lymphoblastic leukemia

Obesity Linked to Adverse Events in Children With Leukemia

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Obesity ups risk for treatment-requiring hypertension, insulin-requiring hyperglycemia
Physicians treating certain cancers who consistently receive payments from a cancer drug's manufacturer are more likely to prescribe that drug instead of other treatments

Drug Company Payments Over Time May Influence Rx Practices

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Payment consistency, high amount, compensation payments tied to cancer drug prescribing practices
An expert panel for the U.S. Food and Drug Administration has endorsed a drug for major depressive disorder that is a close relative to ketamine.

FDA Panel Backs Ketamine-Like Drug for Depression

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Esketamine is a nasal spray that targets different pathways in the brain than other antidepressants do
Although there has been progress in the development of new antibacterial drugs

Progress Made in Developing New Antibacterial Agents

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But most recently approved agents have been modifications of existing chemical classes of antibiotics
The opioid epidemic is driving a steep increase in infection-related stroke hospitalizations

ASA: Opioid Epidemic Tied to Infection-Related Stroke

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Number of hospitalizations steady in 1993 to 2008, but increased significantly in 2008 to 2015
Stroke patients who receive intensive blood pressure lowering are less likely to suffer brain bleeds when treated with clot-busting therapies

ASA: Intensive BP Control Lowers Bleeding Risk in Stroke Patients

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Findings seen among patients with ischemic stroke, high systolic BP receiving alteplase for thrombolysis
Aspirin is underused to reduce the risk for colorectal cancer among patients with advanced colorectal polyps

Aspirin Underused for Advanced Colorectal Polyps

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Only 42.6 percent of 84 patients with biopsy-proven advanced colorectal polyps were taking aspirin
Many systematic review protocols in the International Prospective Register of Systematic Reviews do not include adverse event reporting

Many Systematic Reviews Do Not Fully Report Adverse Events

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Of 146 protocols analyzed, 65 percent fully reported adverse events as intended by the protocol