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Pembrolizumab is noninferior to chemotherapy for overall survival among patients with programmed death ligand 1

ASCO: Pembrolizumab Noninferior to Chemo in Advanced Gastric Cancer

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For patients with PD-L1 combined positive score of ≥10, pembrolizumab prolongs overall survival
The U.S. Food and Drug Administration took a good look at the safety and effectiveness of cannabidiol products on Friday

FDA Takes Hard Look at CBD

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CBD products have swamped the market due to change in federal law, not because of new medical evidence
For callers reporting heroin use

Many Buprenorphine Prescribers Not Offering New Appointments

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However, for those offering new appointments, wait times were not long to receive buprenorphine
Taking proton pump inhibitors is associated with an excess of cause-specific mortality

Excess Cause-Specific Mortality Tied to Chronic Proton Pump Inhibitor Use

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Excess mortality due to CVD, CKD, upper GI cancer for those with no indication for PPI use
Positive cultural beliefs around taking aspirin for prevention of cardiovascular disease are associated with greater adoption of the intervention among African-Americans

Providers, Peers Influence Aspirin Use Among African-Americans

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Positive social environment around a prevention approach may increase uptake, authors say
A public meeting on cannabidiol (CBD) products will be held Friday by the U.S. Food and Drug Administration

FDA to Hold First Public Meeting on CBD

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Scheduled speakers will include doctors, consumers, and cannabis industry members
Less than 60 percent of prescriptions for the treatment of sexually transmitted infections among teens seeking care in the emergency department are filled

Noncompliance Common in Teens Prescribed STI Treatment in ED

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Prescriptions often go unfilled; hospital admission is the only factor associated with prescription filling
Esketamine nasal spray plus an oral antidepressant appears to be a safe and effective treatment for patients with treatment-resistant depression

Esketamine Nasal Spray May Improve Refractory Depression Outcomes

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Findings seen among outpatients with treatment-resistant depression using combo nasal spray, oral antidepressant
The rate of emergency department visits with opioids only given during the visit is higher than the rate for visits with opioids only prescribed at discharge and for visits with opioids given and prescribed

More Opioids Given Than Prescribed in Emergency Department

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Opioids more often given in ED than prescribed at discharge for adult ED visits
The International Pediatric Multiple Sclerosis Study Group has updated standards for future clinical trials in pediatric multiple sclerosis; the new recommendations were published in the May 28 issue of Neurology.

Recommendations Developed for Pediatric Multiple Sclerosis Trials

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Biological rationale exists for using treatments proven efficacious in adults with MS for pediatric MS