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When empirical antimicrobial therapy is initiated in patients with severe manifestations of sepsis

Initiating Empirical Tx for Sepsis Reduces Blood Culture Sensitivity

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12 percent difference seen in proportion of positive blood cultures before and after antimicrobial therapy
Hospital-level high-risk antibiotic use is associated with the risk for hospital-associated Clostridioides difficile infection

High-Risk Antibiotic Use Linked to Hospital-Associated C. Difficile

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High-risk antibiotic use independently predicts hospital-related Clostridioides difficile infection
Men are less knowledgeable than women about human papillomavirus (HPV)

Men Less Knowledgeable About HPV, HPV Vaccination

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Most men and women did not know anal, penile, and oral cancers are caused by HPV
Opioid use at three months after an emergency department visit where opioids were prescribed for acute pain is relatively low and not necessarily tied to opioid misuse

Continued Use Low Three Months After ED Opioid Rx for Acute Pain

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Few report using opioids for reason other than pain three months after receiving opioid Rx
Delaying time to treatment initiation beyond 60 days is associated with decreased overall survival and increased head and neck cancer recurrence

Delaying Treatment Worsens Head, Neck Cancer Outcomes

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Findings show that survival declines, recurrence increases with delays of more than 60 days
Initiating donepezil to manage symptoms of Alzheimer disease or other dementias is associated with a higher risk for 30-day admission to the hospital with rhabdomyolysis compared with initiating rivastigmine or galantamine

Donepezil Ups Risk for Hospital Admission for Rhabdomyolysis

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Donepezil linked to increased risk for admission with rhabdomyolysis versus rivastigmine, galantamine
There are areas for improvement for pediatricians and family physicians in recommendation and delivery methods for the human papillomavirus vaccine

Room for Improvement Found in HPV Vaccine Delivery Practices

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Physicians not strongly recommending vaccine, not using presumptive style linked to refusal or deferral
Acetaminophen use in mid-to-late pregnancy may have an adverse effect on early childhood neurocognitive outcome

Acetaminophen in Pregnancy May Affect Childhood Behavior

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12 variables, mainly features of hyperactive or attentive behavior, tied to acetaminophen use
OxyContin maker Purdue Pharma has filed for Chapter 11 bankruptcy

Purdue Files for Bankruptcy Over Opioid Crisis Suits

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Currently, there are more than 2,600 pending federal and state lawsuits lodged against Purdue
Aspirin for primary prevention of cardiovascular disease is likely to result in net benefit for some patients

Aspirin for Primary Prevention May Offer Net Benefit for Some

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Subgroups with net benefit had higher baseline CVD risk, higher levels of most established CVD risk factors