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Compared with placebo

No Benefit Found for High-Dose Vitamin C Infusions in Sepsis, ARDS

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No differences seen versus placebo in organ dysfunction scores, biomarkers of inflammation or vascular injury
Elderly patients with inflammatory bowel disease are at higher risk for adverse events related to the use of thiopurines

Elderly Who Start Thiopurine Tx for IBD Have Higher Risk for AEs

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Advanced age, female gender are independent risk factors for adverse events
Uptitration of drugs for chronic systolic heart failure stops farther away from the recommended dosage for drugs with higher versus lower recommended dosages

Uptitration of Drugs Varies With Target Dosage in Chronic HF

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When target is higher versus lower dosage, uptitration stops further from recommended dosage
Marine omega-3 supplementation seems to lower the risk for myocardial infarction

Marine Omega-3 Supplements May Lower CVD Risk

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Updated meta-analysis shows lower risks for MI, CHD death, total CHD, CVD death, total CVD
For adults with type 1 diabetes

Glycemic Control Worse Than Thought in Adults With T1DM

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Rates of both acute and chronic complications significantly increase with increasing HbA1c

September 2019 Briefing – Pharmacy

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for September 2019. This roundup includes the latest...
For patients with progressive fibrosing interstitial lung diseases

Nintedanib Slows Fibrosing Interstitial Lung Disease

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Nintedanib linked to lower rate of decline in forced vital capacity versus placebo in phase 3 trial
More patients with advanced melanoma receiving nivolumab plus ipilimumab or nivolumab alone have sustained long-term survival at five years compared with those receiving ipilimumab alone

Nivolumab Therapy Prolongs Survival in Advanced Melanoma

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Overall survival at five years longer with nivolumab + ipilimumab, nivolumab alone versus ipilimumab
Heart disease is associated with an increased risk for hospital admission for allopurinol-associated severe cutaneous adverse reactions

Heart Disease May Up Risk for Allopurinol-Linked Cutaneous AEs

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Risk for hospital admission increased for allopurinol-associated severe cutaneous adverse reactions
In a clinical practice guideline from the American Academy of Pediatrics

Recommendations Updated for Management of Pediatric ADHD

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Recommendations include screening for comorbid conditions, understanding ADHD is chronic condition