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In a clinical guideline published online Feb. 4 in the Annals of Internal Medicine

U.S. Adult Immunization Schedule Updated for 2020

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Shared clinical decision making recommended for HPV in adults age 27 to 45 considered likely to benefit
Timing of treatment start is an important predictor of disability accumulation in patients with pediatric-onset multiple sclerosis

Early Treatment Tied to Less Disability With Pediatric-Onset MS

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Less disability seen among those initiating disease-modifying therapy within two years of clinical onset
Exposure to controlled-release hydromorphone

Hydromorphone-CR Exposure Ups Heart Infection Risk in PWID

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Rates of infective endocarditis increased among PWID exposed to controlled-release hydromorphone
For patients in the emergency department with acute atrial fibrillation

Electrical Cardioversion Effective for Acute A-Fib in Emergency Setting

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Both drug-shock, shock-only strategies highly effective; no difference seen for pad positions
Prescription drug monitoring program data from individual states show a decline in opioid prescribing rates in 11 participating states from 2010 to 2016

Opioid Prescribing Rates Down at State Level From 2010 to 2016

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Among 11 states, daily dosage declined the least in Idaho and Maine, the most in Florida
For patients undergoing living kidney transplants

Promoting Mixed Chimerism Promising in Kidney Transplants

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Complete or partial immunosuppressive drug withdrawal without rejection achieved in some
Many patients who develop new low back pain receive advanced imaging and opioids without having been prescribed nonsteroidal anti-inflammatory drugs or physical therapy

Many Patients Receive Guideline-Nonconcordant Care for Low Back Pain

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One-third of patients received opioids, more than half of whom had not received prescription NSAIDs, PT
A small proportion of providers account for almost half of all opioid doses and about one-quarter of opioid prescriptions

Just a Few Providers Account for Large Number of Opioid Scripts

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Top 1 percent of providers account for 49 percent of all opioid doses, 27 percent of all opioid prescriptions
For patients with unresectable hepatocellular carcinoma

QoL Extended With Atezolizumab + Bevacizumab in Liver Cancer

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And, triplet and doublet drug regimens delay decline in quality of life in BRAF V600E metastatic CRC
Suvorexant improves total sleep time in patients with probable Alzheimer disease dementia and insomnia

Suvorexant May Improve Insomnia With Alzheimer Disease

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Suvorexant does not appear to worsen underlying cognitive impairment