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Treatment escalation options have different efficacy following failure of exenatide or glimepiride added to metformin in patients with type 2 diabetes mellitus

Study Highlights Third-Line Treatment Options for T2DM

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TZD effective post metformin + exenatide; exenatide effective post metformin + glimepiride
For patients undergoing percutaneous coronary intervention

Mortality Up With Spontaneous Bleeding After PCI

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Bleeding associated with increased rate of death, similar to that seen with myocardial infarction
Among people with asthma

NSAID-Exacerbated Respiratory Disease Prevalent With Asthma

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Prevalence about 9 percent; NERD linked to significant increases in asthma morbidity
The quadrivalent human papillomavirus vaccine appears to be cost-effective for the prevention of oropharyngeal cancer among 12-year-old males

HPV4 Vaccine Cost-Effective for OPC Prevention in Teen Boys

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Quadrivalent vaccine appears cost-effective among 12-year-old boys in Canada
Frail

Single-Dose Injection Rx Ups Bone Density in Frail Elderly

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But stronger bones did not translate into fewer fractures in this elderly, high-risk population
For patients with hepatitis C virus

Statin Use Found Beneficial in Hepatitis C Treatment

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Improved virologic response rates, decreased liver fibrosis progression, HCC incidence
A cream formula containing 4 percent hydroquinone

Three-Drug Combo Cream Effective for Melasma

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Compared with other cream formulations, side effects were tolerable
Oral systemic agomelatine has a hypotonising effect that decreases intraocular pressure in both eyes of treatment-resistant primary open angle glaucoma patients

Agomelatine Cuts Ocular Pressure With Glaucoma

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Agomelatine, a melatonin agonist, decreases pressure in stable, consistent way
For patients with cardiomyopathy

ACEi/ARB Use Lowers Incidence of Appropriate ICD Shock

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Lower incidence of appropriate implantable cardiac defibrillator shock in patients with cardiomyopathy
An innovative interdisciplinary program

Art Program Hones Med Students’ Visual Observation Skills

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Students become better at observation and appreciate the importance of communication