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The selective Hedgehog antagonist PF-04449913 seems safe and is tolerated in adults with myeloid malignancies

New Rx for Myeloid Malignancies Moves to Phase II Clinical Trials

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Phase I trial involving 47 patients identified maximum tolerated dose of 400 mg once daily
Adverse reactions to St. John's wort are similar to those reported for fluoxetine

Similar Adverse Effects Seen for St. John’s Wort, Fluoxetine

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Majority reported concern females, 26 to 50 years of age
Millions more Americans have affordable health insurance

Patients Report Improved Care Access, Better Health With ACA

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Gains seen in how many adults have insurance and a doctor, and say they are in better health
For Japanese patients who have undergone percutaneous coronary intervention

Atorvastatin/Ezetimibe Beats Atorvastatin After PCI

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Combination therapy linked to greater coronary plaque regression in Japanese patients
In a position statement published online July 20 in the Journal of Clinical Oncology

ASCO Calls for Cancer Trials to Include More Seniors

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Older adults react differently to treatment, oncology group notes
Chronic supplementation with beetroot juice

Beetroot Juice Supplementation May Help Lengthen Workouts

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Reduction in systolic, diastolic BP, total peripheral resistance at rest and during exercise
Praluent (alirocumab) injection has been approved by the U.S. Food and Drug Administration for use in addition to diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease

FDA Approves Praluent for Certain Cases of High Cholesterol

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First in a new class of injectable cholesterol-lowering medications
About 10 percent of cases where a drug does serious harm are not reported to the U.S. Food and Drug Administration within the required 15-day period

Delays Noted in the Reporting of Serious Patient Harms to FDA

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Analysis found roughly 10 percent of cases were filed after 15-day deadline passed
Topical application of human breast milk is effective for infants with mild to moderate atopic dermatitis

Human Breast Milk Effective for Atopic Dermatitis in Infants

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No significant difference in outcomes for human breast milk, 1 percent hydrocortisone ointment
Eradication of Helicobacter pylori in asymptomatic adults is associated with a reduction in the incidence of gastric cancer

Review: Eradicating H. pylori Cuts Incidence of Gastric Cancer

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Reduction in the incidence of gastric cancer with tx of asymptomatic, otherwise healthy individuals