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Large clinical studies that are sponsored by industry are more likely to report favorable outcomes and less likely to report unfavorable outcomes than those sponsored by the National Institutes of Health

Cardiovascular Trial Sponsorship Significantly Impacts Findings

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Favorable outcomes seven times more likely in industry- versus NIH-sponsored trials
For patients with immunoglobulin A nephropathy

Addition of Immunosuppression No Benefit in IgA Nephropathy

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No improvement in outcomes, more adverse effects for intensive supportive care + immunosuppression
The addition of lixisenatide to usual care does not impact the rate of major cardiovascular events or other serious adverse events among patients with type 2 diabetes and a recent acute coronary syndrome

Lixisenatide Doesn’t Affect Cardiovascular Risk in T2DM

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Findings among patients with type 2 diabetes and recent acute coronary syndrome
For patients with nonspecific chronic low back pain

Vitamin D3, Placebo Both Improve Chronic Low Back Pain

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No significant between-group difference in decrease in mean pain VAS score, mean change in chronic pain
Less frequent laboratory monitoring may be safe for patients receiving isotretinoin for acne as changes in mean values of several laboratory tests do not meet a priori criteria for high-risk

Evidence Doesn’t Support Monthly Labs With Isotretinoin

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Significant changes in values of several laboratory tests, but changes don't meet high-risk criteria
A case before the Supreme Court is potentially threatening patient confidentiality

AMA: Case Before Supreme Court Threatens Patient Privacy

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Case involves Medical Board obtaining three years of prescribing history for doctor, after single complaint
For breast cancer survivors

Anthracyclines More Neurotoxic Than Other Breast CA Regimens

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More negative effects on specific cognitive domains, network connections for breast cancer survivors
For patients with cancer

Safety Concerns Linked to Herbal Medicine Use in Cancer

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Concerns include altered pharmacodynamics, direct toxic effects, increased chemosensitivity
Adding metformin to insulin therapy won't boost glycemic control for overweight teens with type 1 diabetes

Metformin Does Not Boost Glycemic Control in T1DM

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Small, but temporary, beneficial effect from metformin was seen early on

November 2015 Briefing – Pharmacy

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for November 2015. This roundup includes the latest...