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For patients with stage III colon cancer treated with leucovorin

KRAS, BRAF V600E Mutations Impact Survival in Colon Cancer

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Mutations linked to shorter survival in patients with microsatellite-stable tumors
Greater transparency is being promoted in clinical research

Greater Transparency Being Promoted in Research

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Move toward greater transparency has extended beyond medication products to other interventions
For women undergoing hysterectomy

Prophylactic Antibiotic Choice Impacts Post-Hysterectomy SSI

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Increased risk of surgical site infection for those receiving β-lactam alternative, nonstandard regimen
For patients with tuberculous meningitis

Intensified Tx Doesn’t Up Survival in Tuberculous Meningitis

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No significant difference for survival, secondary outcomes for standard, intensified treatment
E-cigarette use actually lowers smokers' chances that they'll quit tobacco by about 28 percent

Electronic Cigarettes May Hinder Smoking Cessation Efforts

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Devices lower chances of quitting by 28 percent, researchers say
Rivastigmine shows potential in reducing the risk of falls among patients with Parkinson's disease

Dementia Rx May Lower Risk of Falls Among Parkinson’s Patients

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Those who took rivastigmine in study were 45 percent less likely to have an accident
U.S. researchers are challenging a leading theory about the nation's heroin epidemic

Pathway to Heroin Described in NEJM Commentary

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Initial exposure to opioids appears to 'push' potential addicts to heroin
Factors associated with failure to achieve a glycated hemoglobin target in the standard therapy arm of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) glycemia trial have been identified

Patient Race Linked to Failure to Achieve HbA1c Target

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Black race, severe hypoglycemia, insulin use linked to failure to reach HbA1c target in ACCORD trial
Initiation of human papillomavirus vaccination is highest among teen girls in poorer communities and in populations that are mainly Hispanic or mixed race

Geographic Factors Impact HPV Vaccine Initiation in Teen Girls

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Higher initiation among girls in high- vs. low-poverty areas, communities with mainly Hispanic, mixed race
Imatinib (Gleevec) blocks CDK5-mediated peroxisome proliferator-activated receptor γ phosphorylation as an antagonist ligand

PPARγ Antagonist Imatinib Improves Insulin Sensitivity

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Imatinib improves insulin sensitivity without causing side effects seen with other PPARγ-targeting drugs