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November 2015 Briefing – Pharmacy

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for November 2015. This roundup includes the latest...
Clozapine reduces symptoms in patients with schizophrenia who don't benefit from other antipsychotic medications

Clozapine Benefits Those With Tx-Resistant Schizophrenia

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Clozapine already approved for use after other antipsychotics don't work
About one in every eight American adults continue to have high levels of total cholesterol

CDC: Cholesterol Levels Improving But More Work Needed

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Adults aged 40 to 59 did not achieve Healthy People 2020 goals in 2011 to 2014
Empliciti (elotuzumab)

FDA Approves Empliciti for Multiple Myeloma

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Monoclonal antibody works with another approved therapy to provide additional benefit
Acyclovir-induced neurotoxicity should be considered for patients with herpes zoster on hemodialysis

Neurotoxicity Seen With Acyclovir at Recommended Dose in Dialysis

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Case report describes acyclovir-induced neurotoxicity in patient treated with recommended dose
Drug-induced aseptic meningitis following trimethoprim use has been described in a research letter published online Nov. 20 in the International Journal of Rheumatic Diseases.

Trimethoprim-Induced Aseptic Meningitis Described

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Case report describes 87-year-old with 3 episodes; decreasing interval between dose, symptoms
For patients with type 2 diabetes

Basal Insulin Peglispro Beats Glargine for Glycemic Control

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In T2DM, also tied to increased triglycerides, aminotransferases, and liver fat content
Taking progesterone supplements in the first trimester of pregnancy may not improve pregnancy outcomes for women with a history of miscarriage

Progesterone May Not Help Prevent Repeat Miscarriage

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Live birth rate 65.8 percent for vaginal progesterone, versus 63.3 percent for placebo
The first seasonal influenza vaccine with an adjuvant has been approved for use in seniors

FDA Approves First Flu Vaccine Containing an Adjuvant

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Adjuvant can enhance or direct the immune response of the vaccinated individual
Both retinol and retinoic acid have beneficial effects on cellular and molecular properties of the epidermis and dermis

Topical Retinol Induces Skin Changes Similar to Retinoic Acid

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Retinoic acid, retinol treatments both increase epidermal thickness, up gene, protein expression