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Factors associated with failure to achieve a glycated hemoglobin target in the standard therapy arm of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) glycemia trial have been identified

Patient Race Linked to Failure to Achieve HbA1c Target

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Black race, severe hypoglycemia, insulin use linked to failure to reach HbA1c target in ACCORD trial
Initiation of human papillomavirus vaccination is highest among teen girls in poorer communities and in populations that are mainly Hispanic or mixed race

Geographic Factors Impact HPV Vaccine Initiation in Teen Girls

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Higher initiation among girls in high- vs. low-poverty areas, communities with mainly Hispanic, mixed race
Imatinib (Gleevec) blocks CDK5-mediated peroxisome proliferator-activated receptor γ phosphorylation as an antagonist ligand

PPARγ Antagonist Imatinib Improves Insulin Sensitivity

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Imatinib improves insulin sensitivity without causing side effects seen with other PPARγ-targeting drugs
Between 2000 and 2009

Newborn Abstinence Sx Up, Tied to Increasing Prenatal Opioid Use

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~14 to 22 percent of pregnant women in the United States are prescribed opioids
Infants are just as susceptible to accidental poisonings as older children are

Infants, Not Just Older Children, at Risk of Accidental Poisonings

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Common dangers include acetaminophen, cough/cold meds, ibuprofen, and diaper rash creams
Gestational exposure to paroxetine in the first trimester is associated with increased risk of major congenital malformations and major cardiac malformations

Review: Paroxetine Use in Pregnancy Tied to Malformations

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Increased risk of any major congenital malformations, major cardiac malformations
New recommendations have been developed for antithrombotic therapy for venous thromboembolism. The Antithrombotic Therapy for VTE Disease: CHEST Guideline was published online Jan. 7 in CHEST.

Recommendations Developed for Antithrombotic Tx in VTE

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Guidelines updated for 12 topics; new recommendations address three new topics
Nivolumab in combination with contact immunotherapy can successfully treat in-transit melanoma

Nivolumab, Contact Immunotx Treats In-Transit Melanoma

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Two cases illustrate successful tx with nivolumab in combination with contact immunotherapy
Azithromycin is frequently prescribed to hospitalized patients despite the presence of risk factors for QTc prolongation

Azithromycin Prescribed Despite Risk for QTc Prolongation

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Seventy-six percent of patients prescribed one or more QTc prolonging meds plus azithromycin
Patients who take statins before and after coronary artery bypass grafting have fewer complications and a reduced mortality risk during and soon after the operation

Statins May Aid CABG Recovery

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Review of statin use indicates reduced risk of death or complications