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Rab3D and Rab27 proteins play an important role in the enhanced release of cathepsin S from lacrimal gland acinar cells in Sjögren's syndrome

New Insight Might Aid Diagnosis, Treatment of Sjögren’s Syndrome

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Mouse model shows role for proteins in enhanced release of CTSS in Sjögren's syndrome patient tears
A new study suggests that excessive amounts of folate and vitamin B12 in a mother's body might increase an infant's risk of developing an autism spectrum disorder. The study findings are scheduled for presentation at the International Meeting for Autism Research

Too Much Folate in Pregnancy Tied to Increased Autism Risk

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Mothers with very high blood levels of folate at delivery twice as likely to have a child with autism
Nilotinib is associated with scurvy

Nilotinib Associated With Case of Scurvy

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Drug appears to affect cutaneous metabolism; patient improved with ascorbic acid supplements
The synthetic prostaglandin E1 analogue misoprostol has known severe side effects and should be considered in cases of postpartum hyperthermia

Misoprostol Should Be Considered in Postpartum Hyperthermia

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Report of 21-year-old with severe hyperthermia, rigors, tachycardia, transient encephalopathy
The endothelin-1 blocker macitentan does not reduce the number of new digital ulcers over 16 weeks among patients with systemic sclerosis and active ischemic digital ulcers

Macitentan Doesn’t Reduce Number of New Digital Ulcers

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Findings over 16 weeks among patients with systemic sclerosis and active ischemic digital ulcers
Esomeprazole accelerates aging of blood vessel cells in lab tests

PPI Exposure Accelerates Aging in Lab Endothelial Cells

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Findings could help explain recent reports linking long-term use to adverse effect on cardiovascular health
Low doses of ketamine may quickly reduce suicidal thoughts in patients with treatment-resistant depression

Ketamine May Ease Suicidal Thoughts in Major Depression

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Small study found that the drug worked quickly in patients with treatment-resistant depression
For patients with lipodystrophy

Metreleptin Ups Resting-State Connectivity in Lipodystrophy

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Significant increases in hypothalamus; insula, superior temporal gyrus; medial prefrontal cortex
A new study suggests that excessive amounts of folate and vitamin B12 in a mother's body might increase an infant's risk of developing an autism spectrum disorder. The study findings are scheduled for presentation at the International Meeting for Autism Research

Too Much Folate in Pregnancy Tied to Raised Autism Risk

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Mothers with very high blood levels of folate at delivery twice as likely to have a child with autism
For patients with acute ischemic stroke

Low-Dose Alteplase Not Noninferior for Ischemic Stroke

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For primary outcome of death and disability at 90 days, low dose not noninferior to standard dose