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Long-term outcomes are more favorable for early intensive treatment versus first-line moderate-efficacy disease-modifying therapy in multiple sclerosis

Early Intensive Treatment May Improve Long-Term MS Outcomes

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Mean five-year change lower in Expanded Disability Status Scale score with early intensive treatment
For first-line therapy of metastatic renal cell carcinoma

Combo Regimens Effective for Tx of Metastatic Renal Cell Cancer

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Two large trials show benefits for pembrolizumab-axitinib and avelumab-axitinib versus sunitinib
Plazomicin is noninferior to meropenem for patients with complicated urinary tract infections

Plazomicin Noninferior to Meropenem for Complicated UTI

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In second study, plazomicin may be beneficial for carbapenem-resistant Enterobacteriaceae infections
A blood test that can quickly diagnose dangerous sepsis infections has been developed

Experimental Test May Quickly Diagnose Sepsis

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Microelectrode device analyzes a patient's blood, provides results in as quickly as 2.5 minutes
The U.S. government may have to take steps to reduce vaccine exemptions for children if states do not do it

FDA Head Says Feds May Intervene to Cut Vaccine Exemptions

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If states do not change lax vaccine laws, federal authorities may be forced to take action
Maternal exposure to fluconazole during pregnancy may increase the risk for spontaneous abortion

Prenatal Fluconazole Exposure Increases Neonatal Risks

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Any exposure increases spontaneous abortion risk; cardiac septal defects up for use in early pregnancy
Metastasis-free survival is significantly longer among men with nonmetastatic

Darolutamide Slows Spread of Castration-Resistant Prostate Cancer

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Significant survival benefit seen, adverse events similar between darolutamide and placebo
Despite adequate levels of prescriber

Inappropriate Use of Fentanyl Preps Seen Despite Awareness

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Claims data show many prescribed transmucosal immediate-release fentanyl were opioid-nontolerant
For patients with an admitting diagnosis of acute coronary syndrome and/or acute decompensated heart failure

Discharge Opioid Rx for Heart Dz Patients May Impact Follow-Up

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Findings seen in patients with admitting diagnosis of acute coronary syndrome, decompensated heart failure
Age

Risk Factors ID’d for Diffuse Large B-Cell Lymphoma Mortality

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In older patients, risk factors include advanced age, DLBCL stage, Charlson Comorbidity Index