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More patients with advanced melanoma receiving nivolumab plus ipilimumab or nivolumab alone have sustained long-term survival at five years compared with those receiving ipilimumab alone

Nivolumab Therapy Prolongs Survival in Advanced Melanoma

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Overall survival at five years longer with nivolumab + ipilimumab, nivolumab alone versus ipilimumab
Heart disease is associated with an increased risk for hospital admission for allopurinol-associated severe cutaneous adverse reactions

Heart Disease May Up Risk for Allopurinol-Linked Cutaneous AEs

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Risk for hospital admission increased for allopurinol-associated severe cutaneous adverse reactions
In a clinical practice guideline from the American Academy of Pediatrics

Recommendations Updated for Management of Pediatric ADHD

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Recommendations include screening for comorbid conditions, understanding ADHD is chronic condition
Real-world evidence shows that rivaroxaban reduces the risk for recurrent venous thromboembolism in morbidly obese patients

Rivaroxaban Cuts Recurrent Blood Clots in Obese Patients

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Patients on rivaroxaban also have lower health care resource utilization than those on warfarin
The crude incidence of candidemia was 8.7 per 100

Crude Incidence of Candidemia 8.7 Per 100,000 in 2012 to 2016

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Incidence highest in older adults (≥65 years); higher for men than women, blacks versus nonblacks
CVS is the latest drugstore chain to stop selling over-the-counter Zantac (ranitidine)

CVS Halts Sales of OTC Zantac

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Tests have found low levels of the nitrosamine impurity NDMA in some ranitidine products
Short-term use of a dipeptidyl peptidase 4 inhibitor for the treatment of diabetes does not increase the risk of inflammatory bowel disease

DPP4 Inhibitors Do Not Up Risk of Inflammatory Bowel Disease

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Findings based on comparison to sulfonylureas, thiazolidinediones
In new American Gastroenterological Association clinical practice guidelines

Recommendations Developed for Evaluating Chronic Diarrhea

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AGA recommends fecal calprotectin, lactoferrin for screening for inflammatory bowel disease
Mortality is lower for patients with candida bloodstream infection receiving an infectious disease consultation

Infectious Disease Consultation May Lower Candida Mortality

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Mortality at 90 days lower in patients with candida bloodstream infection who receive an ID consult
Eight candidate touchpoints are associated with increased risk of fatal opioid overdose

Eight Touchpoints May Predict Opioid Overdoses

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These factors identify more than half of opioid overdose decedents and may represent prevention opportunities