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Upadacitinib is superior to abatacept for patients with rheumatoid arthritis refractory to biologic disease-modifying antirheumatic drugs

Upadacitinib Tops Abatacept for RA Refractory to DMARDs

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Superior for mean change in composite DAS28-CRP values and remission, but more adverse events seen
Manualized psychotherapy interventions combined with pharmacotherapy seem beneficial for bipolar disorder

Pharmacotherapy, Psychotherapy Combo Best for Bipolar Disorder

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Manualized treatments linked to significantly reduced recurrence rates versus control treatments
Women who experience their first myocardial infarction at ≤50 years of age are less likely than men to undergo coronary revascularization or be treated with guideline-directed medical therapies

Outcomes Worse for Women With MI at 50 Years or Younger

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Women less likely to undergo coronary revascularization, receive guideline-directed medical treatment
The U.S. Food and Drug Administration is requiring labeling changes to nonsteroidal anti-inflammatory drugs that warn of the risks of taking these drugs at 20 weeks of pregnancy or later

FDA Requiring Labeling Changes to NSAIDs Warning of Risks in Pregnancy

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Labeling must indicate risks to unborn baby with NSAID use at 20 weeks of pregnancy or later
Use of aspirin

Use of Common Meds Tied to Lower Lung Cancer Mortality

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Combined use of aspirin, statins, metformin tied to lower lung cancer risk and mortality
Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of Oct. 12 to 16

Physician’s Briefing Weekly Coronavirus Roundup

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Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...
Ertugliflozin is noninferior to placebo with respect to major adverse cardiovascular events among patients with type 2 diabetes and atherosclerotic cardiovascular disease

Ertugliflozin Noninferior for CV Outcomes in T2DM With ASCVD

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Ertugliflozin is noninferior to placebo for the primary end point of major adverse cardiovascular events
New cannabinoid use is associated with elevated rates of adverse outcomes among older adults with chronic obstructive pulmonary disease

Cannabinoid Use Tied to Adverse Outcomes With COPD

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In older adults with COPD, cannabinoid use tied to all-cause mortality, hospitalizations
Polypharmacy

Polypharmacy Common in Seniors With Heart Failure

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With increasing number of medications, more rapid increase seen in number of noncardiovascular meds
Enrollment in a study testing an experimental antibody therapy against COVID-19 has been paused by independent monitors.

COVID-19 Antibody Treatment Study Paused

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ACTIV-3 study, testing use of an antibody therapy with remdesivir, paused 'out of an abundance of caution'