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Use of a faulty device in a regulatory drug trial has raised questions relating to rivaroxaban use

Safety Issues Raised in Key Trial Supporting Rivaroxaban Use

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Defective point-of-care device used in warfarin arm of ROCKET AF trial calls results into question
Patients with minimal exposure to benzodiazepine have a slightly increased risk of dementia

Minimal Benzodiazepine Exposure May Up Dementia Risk

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However, higher benzodiazepine use is not associated with more rapid cognitive decline
Routine use of amoxicillin does not improve nutritional recovery from uncomplicated severe acute malnutrition in children

Routine Amoxicillin Use of No Benefit in Acute Malnutrition

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No difference versus placebo for nutritional recovery in children with severe acute malnutrition
Patients who self-report penicillin allergy might actually have chronic urticaria

Self-Reported Penicillin Allergy May Actually Be Chronic Urticaria

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Penicillin allergy or other self-reported allergies should be tested, researchers say
For obese women

Antenatal Metformin Cuts Maternal Weight Gain in Obese

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Findings among women without diabetes with BMI of >35; no reduction in neonatal birth weight
Although full influenza vaccination coverage is increasing among children aged 6 to 23 months

Less Than Half of U.S. Infants Fully Vaccinated for Influenza

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Increase in full vaccination coverage from 4.8 percent in 2002-2003 to 44.7 percent in 2011-2012
Acetazolamide does not differ from placebo in effect on the duration of invasive mechanical ventilation in patients with chronic obstructive pulmonary disease

Intubation Duration for COPD Unchanged by Acetazolamide

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Randomized trial shows no difference vs placebo in duration of invasive mechanical ventilation
During long-term follow-up

Neutral Long-Term Effect for Intensive Glycemic Control

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Follow-up of patients from ACCORD trial shows neutral effect on primary composite outcome
The Advisory Committee on Immunization Practices has approved the recommended adult immunization schedule for 2016. The recommendations are published as a clinical guideline in the Feb. 2 issue of the Annals of Internal Medicine.

ACIP Approves 2016 Adult Immunization Schedule

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Changes to schedule for HPV, pneumococcal, and meningococcal vaccines
The 2016 recommended immunization schedule for children and adolescents has been approved

2016 Childhood Immunization Schedule Released

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Changes to schedule include earlier HPV vaccination for children with a history of sexual abuse