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Semaglutide Not Linked to Increased Risk of Eye Disorders, Diabetic Retinopathy

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Semaglutide linked to increased risk of nonarteritic anterior ischemic optic neuropathy, but evidence remains insufficient to establish definitive conclusion

COVID-19 mRNA Vaccine Targeting Omicron JN.1 Lineage Safe

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No significant increases seen in rate of hospital contacts for any of 29 adverse events in 28-day risk period after vaccination

GLP-1 Receptor Agonist Use Linked to Nonarteritic Anterior Ischemic Optic Neuropathy

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Association seen in seniors with type 2 diabetes; greater associations seen for semaglutide and liraglutide

Glipizide Linked to Highest MACE-4 Risk in Individuals With Type 2 Diabetes

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Highest risk seen with glipizide versus other sulfonylureas and DPP4 inhibitors as second-line therapy

Standardization Needed for Dialysis Initiation in Pregnancy

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Women who started dialysis during pregnancy more often had adverse maternal and fetal outcomes

GLP-1 Receptor Agonist Use in T2D Tied to Increased Risk for GERD, GERD Complications

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Risk ratios were 1.27 and 1.55 for GERD and its complications during a median follow-up of three years for GLP-1 RA versus SGLT-2 inhibitor users

Many Ineligible for Clinical Trial Could Benefit From Teclistamab for Multiple Myeloma

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89 percent of 509 patients would have been ineligible for MajesTEC-1 trial; estimated median PFS was 5.8 months

Anticholinergics Tied to Physical Performance Decline in Older Adults

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Authors say findings support guidance to avoid these medications when possible

Gabapentin for Back Pain Linked to Increased Risk for Dementia, MCI

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Further increase in risk was seen with prescription frequency, with higher risk for 12 or more prescriptions

Increased Liver Enzyme Levels Seen With Use of Cannabidiol in Adults

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Cannabidiol within the range consumers are taking with unregulated products linked to increase in liver enzymes