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Tag: Vaginal Problems

5-fluorouracil is associated with a 74 percent success rate as the initial treatment modality for high-grade intraepithelial vaginal dysplasia

5-Fluorouracil Promising for Vaginal Intraepithelial Neoplasia

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High success rate seen for 5-fluorouracil as initial treatment modality; also promising for recurrences
Use of a fractional carbon dioxide laser is a safe and effective treatment for genitourinary symptoms of menopause

Laser Tx Aids Genitourinary Symptoms of Menopause

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Women report decreased vaginal dryness, increased frequency of intercourse
For breast cancer survivors who are premenopausal at diagnosis

pH-Balanced Vaginal Gel Doesn’t Improve Dyspareunia

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No difference versus placebo for sexual function, frequency of sexual dysfunction for breast cancer survivors
For postmenopausal women undergoing surgical treatment for pelvic organ prolapse

Estriol Gel Aids Vaginal Health Pre, Post Genital Prolapse Sx

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Significant improvement in vaginal health before and after surgery for pelvic organ prolapse
Vulvar and vaginal melanomas have unique molecular features as compared to nongynecologic melanoma

Unique Molecular Features for Vulvar, Vaginal Melanomas

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BRAF most frequently mutated gene in VVMs, while NRAS mutations are rarely seen
Intrarosa (prasterone) has been approved by the U.S. Food and Drug Administration to treat women who have moderate-to-severe pain during sexual intercourse caused by postmenopausal vulvar and vaginal atrophy.

FDA Approves Intrarosa for Postmenopausal Pain During Sex

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Drug contained in a once-daily vaginal insert
For postmenopausal women with early-stage breast cancer taking aromatase inhibitors

Intravaginal Testosterone Deemed Safe in Early Breast CA

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Findings in postmenopausal women with early-stage breast cancer receiving aromatase inhibitors
For pregnant women

Oral Probiotics Have No Impact on Vaginal Health in Pregnancy

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Similar decrease in proportion of normal vaginal microbiota for treatment, placebo groups
Women with vaginal mesh with complications have a significantly increased proinflammatory response

Proinflammatory Response in Women With Vaginal Mesh

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Significantly higher M1/M2 cytokines, chemokines, MMP-9 and -2 in women with mesh-vagina explants
Women with vaginal mesh with complications have a significantly increased proinflammatory response

Proinflammatory Response in Women With Vaginal Mesh

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Significantly higher M1/M2 cytokines, chemokines, MMP-9 and -2 in women with mesh-vagina explants