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Seizure Risk Up for Seniors in Nursing Homes Prescribed Tramadol and Antidepressants

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Risk for seizures increased with concomitant use of tramadol with CYP2D6-inhibiting versus neutral antidepressants

For older adults

Tramadol Linked to Increased Hip Fracture Risk in Adults Aged ≥50

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Risk for hip fracture over one year higher for those initiating tramadol compared with codeine, common NSAIDs