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In children with latent tuberculosis

Rifampin Effective for Latent Tuberculosis in Children

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Rifampin has advantage of being a shorter, single-drug regimen that is palatable for children
A four-month regimen of rifampin is similar to a nine-month regimen of isoniazid for the prevention of active tuberculosis

Rifampin Similar to Isoniazid for Preventing Active Tuberculosis

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Rifampin has significantly higher rate of treatment completion, fewer drug-related adverse events
Most people complete treatment for latent tuberculosis without direct observation

Completion Likely With Self-Administration of TB Treatment

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Self-administration without reminders is noninferior to direct observation in patients with latent TB
An automated molecular assay can detect Mycobacterium tuberculosis with resistance to drugs directly from sputum specimens

Assay Can ID M. tuberculosis Resistance Mutations

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Assay detects mutations associated with resistance to isoniazid, fluoroquinolones, aminoglycosides

Change in Conversion Definition May Improve TB Detection

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Increase from IFNγ <0.2 to >0.7 IU/mL would improve identification of those at risk of tuberculosis
Isoniazid monotherapy

Meta-Analysis Compares Efficacy of Therapies for Preventing TB

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Isoniazid, rifampicin monotherapy, combination therapies can prevent active TB in latent TB infection
Multidrug-resistant and extensively drug-resistant tuberculosis are expected to increase through 2040

Multidrug-Resistant TB Set to Increase Through 2040

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Increase in percentage of MDR tuberculosis, XDR tuberculosis in India, Philippines, Russia, S. Africa
Deep learning with deep convolutional neural networks can result in accurate detection of tuberculosis on chest radiographs

Deep Convolutional Neural Networks Accurately Detect TB

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Ensemble of AlexNet and GoogLeNet was best-performing classifier, with AUC of 0.99
For patients with rheumatoid arthritis

Infection Risk Lower for Etanercept Vs Monoclonal Ab Rx

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Findings from meta-analysis of patients with rheumatoid arthritis
Migrants from countries with a high incidence of tuberculosis who undergo screening before entry to low-incidence countries pose a negligible risk of onward transmission but are at increased risk of the infection

Migrants Screened for Active TB Pose Negligible Transmission Risk

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Screening, monitoring, treatment important in continuing downward trend of tuberculosis incidence