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Artificial sweeteners don't contain the calories or energy that evolution has trained the brain to expect from sweet-tasting foods

Hormone May Be Key to Sugar, Diet Sweetener Response

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In experimental model, disruption of Dh44 linked to failure to select nutritive sugars
Exchanging one sugar-sweetened beverage for water or unsweetened coffee or tea daily could lower diabetes risk by up to 25 percent

Drop Just One Sugar-Sweetened Drink Daily, Drop DM Risk Greatly

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Drinking water, unsweetened tea or coffee instead lowered risk by 25 percent
Sucrose

Sucrose Intake Linked to Higher Activity in Left Hippocampus

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Sucrose, but not aspartame, consumption linked to reduced stress-induced cortisol
Reducing consumption of added sugars

Cutting Added Fructose Could Reduce Diabetes-Linked Morbidity

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Limiting intake to 5 percent of calories would improve glucose tolerance, reduce diabetes prevalence
Girls who consume a lot of sugary drinks may begin menstruating earlier than girls who don't

Sugary Drink Consumption Tied to Earlier Menarche

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Early menstruation a risk factor for depression and breast cancer