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Tag: Stem Cells

Ixmyelocel-T

ACC: Ixmyelocel-T Beneficial for Heart Failure With Reduced EF

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Significant reduction in primary efficacy end point with ixmyelocel-T therapy
An in vivo transplantation model has been used to develop a three-dimensional integumentary organ system from induced pluripotent stem cells

Bioengineering Advances Offer Promise for Skin Regeneration

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3D integumentary organ system developed from induced pluripotent stem cells using in vivo model
Defitelio (defibrotide sodium) has been approved by the U.S. Food and Drug Administration to treat a rare

FDA Approves First Tx for Disease Linked to Stem Cell Transplant

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Hepatic veno-occlusive disease is rare, but fatal
Stepwise differentiation through an enriched retinal progenitor intermediary facilitates the accomplishment of deriving retinal ganglion cells from human pluripotent stem cells

Retinal Ganglion Cells Derived From Pluripotent Stem Cells

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Increase in apoptosis in patient-derived RGCs, which was rescued with candidate neuroprotective factors
A new surgical technique for removing cataracts might allow the eye's stem cells to regenerate a healthy lens

Treating Infant Cataracts With Endogenous Stem Cells Feasible

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Leaving cells behind during removal of damaged tissue leads to regeneration of new, clear lens
A considerable proportion of patients undergoing hematopoietic stem cell transplantation meet the criteria for posttraumatic stress disorder and depression at six months after the procedure

PTSD, Depression Common After Stem Cell Transplant

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Decline in QOL and increase in depressive symptoms during hospitalization predict six-month outcomes
Treatment of exaggerated scars with dermal autologous micrografts appears effective

Dermal Autologous Micrograft May Be Effective Scar Treatment

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With further validation may be innovative regenerative treatment for scars
Use of bone marrow as the stem cell source for hematopoietic stem cell transplantation increases with increasing incomes

Stem Cell Sources Used for HSCT Vary by Country, Resources

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Use of bone marrow most common in Americas, Europe; increases with increasing income
Antibody therapy before stem cell transplant may benefit patients with acute leukemia

Antibody Tx Reduces Graft-vs-Host Post Stem Cell Transplant

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Results for patients with acute leukemia
For adult patients with refractory Crohn's disease with impaired quality of life

HSCT Not Linked to Sustained Remission in Refractory Crohn’s

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More patients undergoing HSCT able to discontinue treatment for at least three months