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Using statins for as short a time as three months can put patients at risk for developing diabetes and skin and soft tissue infections

Risk for Skin Infections, Diabetes Increase With Statin Use

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Study shows mechanism of statins can induce onset of diabetes
Statin therapy is not associated with increased decline in memory or cognition among older adults

Statin Use Not Linked to Rate of Cognitive Decline in Seniors

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Rate of decline in memory, global cognition similar for elderly statin users, never users over six-year period
A high proportion of patients with atherosclerotic cardiovascular disease do not achieve recommended low-density lipoprotein cholesterol goals

AHA: Many With Atherosclerotic CVD Not Meeting LDL-C Goals

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Of those patients receiving only a statin, 67.0 percent did not achieve recommended LDL-C goal
Implementation of guidelines for lipid management in 2013 correlated with a reduction in mean total cholesterol

Cholesterol Levels Have Been Dropping Since 2013 Guidelines

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Total cholesterol, triglycerides, LDL-C levels decreased; proportion of eligible adults taking statins increased
Initiation of statin therapy during childhood in patients with familial hypercholesterolemia slows the progression of carotid intima-media thickness and reduces the risk for cardiovascular disease over 20 years

Statins in Childhood Aid Familial Hypercholesteremia Outcomes

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Patients show slowed progression of carotid intima-media thickness, lower risk for cardiovascular disease
There is a dose-dependent relationship between diagnosis of osteoporosis and statin treatment

Statins Tied to Osteoporosis in Dose-Dependent Manner

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Low-dose statins may offer protective effect against osteoporosis
Lipophilic statin use is associated with significantly reduced hepatocellular carcinoma incidence and mortality in adults with chronic viral hepatitis

Lipophilic Statins May Cut Liver Cancer in Chronic Viral Hepatitis

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Inverse link is dose-dependent; lowest 10-year HCC risk seen with 600 or more lipophilic statin cDDDs
Among patients hospitalized for acute coronary syndrome

High-Intensity Lipid Lowering May Aid Very Elderly After ACS

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Benefit of simvastatin-ezetimibe combo after acute coronary syndrome greatest for patients ≥75 years
For elderly patients taking statins for primary prevention

Discontinuing Statins Linked to Cardiac Admissions in Elderly

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Admission risk for any cardiovascular event up with discontinuation among previously adherent seniors
There may be a dose-dependent relationship between statin therapy and new-onset diabetes across the duration of statin use

Statin Use Associated With Higher Incidence of Diabetes

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Findings show statin use tied to higher HbA1c values, with longer statin use tied to greater risk for diabetes