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Statins reduce the rate of vascular events regardless of patient age

Statins Cut Risk for Major Vascular Events in Older Patients

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Effects seen even among patients older than 75 years, though with less direct evidence of benefit
Individuals using statins may be at higher risk for hyperglycemia

Statins Tied to Insulin Resistance, Higher Serum Fasting Insulin

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Ever use of statins associated with 38 percent increased risk for incident type 2 diabetes
Few patients are optimally adherent to statins

ACC: Adherence to Statins Low Among Patients With ASCVD

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Adherence linked to significantly reduced risk for MACE, but only 6.4 percent had optimal compliance
For Taiwanese patients with type 2 diabetes and dyslipidemia

Statin Therapy Reduces Risk for Diabetic Retinopathy in T2DM

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Reduced risk, slowed progression of retinopathy for Taiwanese patients with type 2 diabetes, dyslipidemia
Adherent patients receiving high-intensity statin and/or ezetimibe therapy have the lowest cardiovascular risk

Adherence and Intensity of Lipid-Lowering Tx Influence CV Risk

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Lowest risk seen for adherent patients receiving high-intensity statin and/or ezetimibe regimen
Statins are associated with a low risk for side effects

AHA Scientific Statement: Low Risk of Side Effects for Statins

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Risk for statin-induced serious muscle injury <0.1 percent, newly diagnosed diabetes ~0.2 percent
The onset of musculoskeletal adverse events during statin monotherapy is significantly faster with use of atorvastatin and rosuvastatin versus simvastatin

Onset of Musculoskeletal Adverse Events Varies Between Statins

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Significantly faster onset with atorvastatin, rosuvastatin versus simvastatin during monotherapy
First-year nonadherence and discontinuation are high among older adults prescribed statins

Nonadherence, Discontinuation of Statins High in 1st Year of Rx

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Among older adults prescribed statins, diabetes, anxiety linked to nonadherence, discontinuation
There is a lack of convincing evidence for an association between statin use and non-cardiovascular disease outcomes

Link Between Statins, Non-CVD Outcomes Lacks Evidence

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Review of observational studies, randomized trials shows absence of convincing evidence
Preoperative statin therapy is associated with higher long-term survival following abdominal aortic aneurysm repair

Statins Improve Long-Term Survival After AAA Repair

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Findings in those taking statins before abdominal aortic aneurysm repair or initiating before discharge