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Inhibition of sclerostin with romosozumab may increase cardiovascular risk

Inhibition of Sclerostin May Increase Cardiovascular Risk

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SOST genetic variants linked to lower risk for fracture and osteoporosis but higher risk for MI, major CV AEs
There is a small increased risk for subdeltoid bursitis after influenza vaccination

Small Increase Seen in Risk for Subdeltoid Bursitis With Flu Shot

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Attributable risk was 7.78 additional cases of subdeltoid bursitis per million persons vaccinated
Patients with COVID-19 who receive hydroxychloroquine have a high risk for corrected QT prolongation

Hydroxychloroquine in COVID-19 Ups Risk for QTc Prolongation

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Concurrent treatment with azithromycin linked to greater changes in corrected QT interval
Anticholinergic burden is associated with adverse outcomes in a middle- to older-aged population

Anticholinergic Burden Tied to Adverse Effects in Middle Age

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Identification of at-risk populations varies by scale used, which could impact clinical practice
Asthma and allergy drug montelukast -- sold as a generic and under the brand name Singulair -- will get a "boxed warning" over potential ties to neuropsychiatric effects

FDA: Singulair to Get ‘Black Box’ Warning

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Drug has long carried warning of potentially dangerous neuropsychiatric side effects
Long-term antidepressant use increases the risk for type 2 diabetes onset in a time- and dose-dependent manner

Long-Term Antidepressant Use Appears to Raise Risk for T2DM

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Study suggests glucose tolerance improves with antidepressant discontinuation or dose reduction
A higher proportion of older and multimorbid patients with type 2 diabetes achieve low hemoglobin A1c levels

HbA1c Levels Lower in Older, Multimorbid Patients With T2DM

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Patients with higher comorbidity burden more likely to be treated with insulin for T2DM
Obesity is associated with an increased risk for cardiotoxicity among patients receiving treatment for breast cancer

Obesity May Up Cardiotoxicity Risk From Breast Cancer Therapy

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Obesity independently associated with treatment-related cardiotoxicity in breast cancer patients
Among patients with moderately severe Parkinson disease

SAE Rate Higher With Nilotinib Versus Placebo in Parkinson Disease

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Exploratory biomarkers altered in response to nilotinib, including drop in hyperphosphorylated tau
Accelerated partial breast irradiation delivered twice per day over one week to the tumor bed is noninferior to whole breast irradiation for preventing ipsilateral breast tumor recurrence

Results Mixed for Twice-Daily APBI in Early Breast Cancer

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APBI noninferior to WBI for preventing recurrence but linked to increased late toxicity, adverse cosmesis