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New research supports expanded restrictions on opioid-containing cough and cold medications for children

Data Support FDA Restrictions on Child Cough and Cold Medicines

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Surveillance data showed more adverse events for children exposed to hydrocodone than codeine
The U.S. Food and Drug Administration has strengthened current warnings in the prescribing information about fluoroquinolone antibiotics causing significant decreases in blood glucose as well as mental health side effects.

FDA Requires Safety Label Changes for Fluoroquinolones

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Changes will describe hypoglycemic coma and clarify and identify mental health side effects
The estimated prevalence of using medications with depression as an adverse effect is 37.2 percent

Meds With Depression As Adverse Side Effect Commonly Used

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Prevalence of depression higher for adults reporting use of multiple meds with depression as side effect
For prostate cancer survivors

Prostate Cancer Treatment Side Effects Linked to Distress

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Those with worse emotional distress also report worse urinary, sexual, bowel functions
Patients receiving immunotherapy with antiprogrammed cell death protein-1 and antiprogrammed cell death ligand-1 monoclonal antibodies may develop uveal effusion

Uveal Effusion Reported After Initiation of Anti-PD-1, -PD-L1

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Case series IDs three patients who developed uveal effusion within one to two months of initiating tx
To help curb complications tied to the permanent contraceptive implant Essure

FDA Puts New Restrictions on Contraceptive Implant Essure

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Patients and physicians must sign acknowledgment of risks, benefits of implantation
The overall incidence of adverse effects and serious adverse effects is similar in patients with type 2 diabetes mellitus taking dapagliflozin or placebo

Rate of Adverse Effects for Dapagliflozin Similar to Placebo

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Although genital infections, renal function AEs found more frequently with dapagliflozin than placebo
Ropinirole

Highest Adverse Effect Rates for Three Drugs in Parkinson’s

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Incidence rates of dyskinesia were highest with ropinirole; also linked to high incidence of nausea
Montelukast appears to be linked to neuropsychiatric side effects

Montelukast Associated With Nightmares, Depression

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Odds of depression, aggressive behavior, suicide ideation, nightmares, headaches all increased
Severe vaccine reactions recur rarely

Low Rate of Recurrence Seen for Serious Reactions to Vaccines

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Findings add to evidence of safety of childhood immunizations, pediatricians say