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Initiation of therapy with sodium-glucose cotransporter-2 inhibitors for type 2 diabetes mellitus is not associated with an increased risk for urinary tract infection events compared with initiation of other second-line antidiabetic medications

SGLT-2 Inhibitor Use Not Linked to Increased Risk for UTI Events

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Findings seen in propensity-matched cohorts versus receipt of DPP-4 inhibitors or GLP-1 agonists
For patients with relapsed multiple myeloma

Cardiovascular AEs Common With Carfilzomib in Multiple Myeloma

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Patients with relapsed multiple myeloma experiencing CVAEs had inferior survival
Cardiac radiation dose exposure is a modifiable cardiac risk factor for major adverse cardiac events and all-cause mortality in patients with non-small cell lung cancer

Cardiac Radiation Dose in NSCLC Predicts Mortality, Cardiac AEs

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In coronary heart disease-negative patients, mean heart dose associated with all-cause mortality
Gabapentinoids are associated with increased risks for adverse outcomes related to coordination disturbances

Gabapentinoids Linked to Increased Risk for Significant Adverse Outcomes

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Risk increased for suicidal behavior, unintentional overdose, road traffic incident, head/body injuries
Consumption of dietary supplements

Dietary Supplements May Up Risk for Severe Medical Events

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Increased risk seen in association with supplements sold for muscle building, energy, weight loss
The risk for adverse drug reactions may be higher for women

Gender Differences Seen in Adverse Drug Reactions

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Differences found in reaction symptoms and types of drugs tied to adverse reactions
Chemotherapy patients who suck on ice chips during treatment with oxaliplatin infusion have less trouble with eating and drinking cold things

Sucking Ice Chips Cuts Oral Side Effects of Oxaliplatin Chemo

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Benefits include less trouble eating and fewer symptom-related negative effects on quality of life
For patients with chronic myeloid leukemia

Reasons for TKI Discontinuation ID’d in Chronic Myeloid Leukemia

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Treatment-free remission maintained in 14 of 21 patients who discontinued tyrosine kinase inhibitors
A patient-report instrument has good predictive value for identifying adverse drug events in older adults in the community setting

Patient-Report Instrument Helps Identify ADEs in Older Adults

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With accuracy of 75 percent, tool differentiates between symptoms of adverse drug events, chronic disease
Many systematic review protocols in the International Prospective Register of Systematic Reviews do not include adverse event reporting

Many Systematic Reviews Do Not Fully Report Adverse Events

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Of 146 protocols analyzed, 65 percent fully reported adverse events as intended by the protocol