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Tag: Sickle-Cell Anemia

High-dose crizanlizumab treatment is associated with a significantly lower rate of sickle cell-related pain crises than placebo

ASH: Lower Rate of Sickle Cell Pain Crises With Crizanlizumab

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Lower rate of crises per year; longer median time to first, second crises with high-dose therapy
Sickle cell trait is not associated with a higher risk of death than absence of the trait

Sickle Cell Trait Doesn’t Up Mortality Risk in U.S. Soldiers

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However, SC trait was linked with significantly higher risk of exertional rhabdomyolysis
Hydroxyurea may help preserve lung function in children with sickle cell disease

ATS: Hydroxyurea Can Up Lung Function in Sickle Cell Disease

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Drug slowed down the annual decline children had been showing before starting treatment
The rate of vaso-occlusive crisis events is not significantly lower for children and adolescents with sickle-cell anemia receiving prasugrel versus placebo

ASH: Prasugrel Doesn’t Cut Vaso-Occlusive Crisis in Sickle Cell

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Rate of vaso-occlusive crisis events is not lower for children receiving prasugrel versus placebo
Less than one-quarter of sickle cell anemia patients who should have been taking hydroxyurea within a year of their last pain crisis actually were taking the medication

Hydroxyurea Underutilized for Patients With Sickle Cell

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Only 23 percent using the drug within a year of their last pain crisis