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Hydrocortisone Does Not Reduce 90-Day Mortality in Septic Shock

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Small reduction in mortality seen with use of hydrocortisone with fludrocortisone

Hydrocortisone Plus Fludrocortisone Superior for Septic Shock

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Compared with hydrocortisone alone, combo significantly cuts risk for in-hospital death or hospice discharge

Azithromycin Cuts Maternal Sepsis, Death in Vaginal Delivery

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For women planning vaginal delivery, azithromycin linked to lower risk for maternal sepsis or death

Cardiovascular Hospitalization Increased After Sepsis Hospitalization

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Patients discharged after sepsis hospitalization have increased risk for all-cause mortality, all-cause rehospitalization

Restrictive, Liberal Fluid Strategies Yield Similar Outcomes for Sepsis-Induced Hypotension

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All-cause death before discharge home by day 90 occurred in 14.0 percent of the restrictive fluid group and 14.9 percent in the liberal fluid group

Late-Onset Meningitis ID’d in 1 Percent of Extreme Preemies

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Performance of lumbar puncture has decreased in late-onset sepsis evaluations; 16 percent of late-onset meningitis cases occurred without late-onset sepsis

7.7 Million Deaths Associated With 33 Bacterial Pathogens in 2019

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Deaths associated with these pathogens comprised 13.6 percent of all global deaths, 56.2 percent of all sepsis-related deaths

AI Algorithm May ID Dysfunctional Immune Profiles in Acute Infection

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Machine learning framework used to deploy quantitative sepsis response signature score, which was estimated using seven- or 12-gene signature

Pediatric Sepsis Survivors May Face New, Progressing Comorbidities

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Nearly one in five have new or worsening medical condition versus nonsepsis critical care survivors

Early Warning System Can Identify Sepsis Patients

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Patients whose alert was confirmed by provider within three hours had reduced in-hospital mortality rate