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ENDO: Sweeteners, Genetic Predisposition Independently Linked to Early Puberty

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No significant interaction effects seen between genetic predisposition and sweetener intake for central precocious puberty risk

Considerable Uncertainty Exists Regarding Effects of Puberty Blockers

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Two systematic reviews revealed very low-certainty evidence on outcomes for people with gender dysphoria

Gender-Affirming Medication Use Rare in U.S. Transgender Adolescents From 2018 to 2022

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Findings seen among privately insured adolescents who identify as transgender and gender-diverse

Evidence Lacking for Gender Dysphoria Treatments for Teens

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Two systematic reviews show inadequate evidence for use of treatment to suppress or lessen effect of puberty, hormone treatment

Timing of Pubertal Development Tied to Adult Cardiometabolic Risk

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Later breast development, pubic hair onset, and menarche onset each predict lower adulthood risk

Prenatal Psychological Distress Linked to Earlier Adrenarche in Girls

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Fetal exposure to elevated maternal psychological distress predicts earlier adrenarche and higher DHEA-S levels

Incidence of Idiopathic Central Precocious Puberty Higher During COVID-19

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Girls in Italy diagnosed during the COVID-19 pandemic spent about two hours/day on electronic devices; most stopped physical activity

Markers of Puberty Differ in Girls With More Body Fat

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Girls with higher total body fat have delayed breast maturation, as determined by breast ultrasound, and earlier menarche

Earlier-developing adolescents represent a group at increased risk for self-harm

Timing of Puberty Linked to Risk for Self-Harm in Adolescence

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Earlier puberty associated with higher risk for self-harm at 16 years of age
For men

Early Age at Puberty Linked to Increased T2DM Risk in Men

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Early age at peak height velocity also an independent predictor for insulin treatment for T2DM