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AAN: Tavapadon as Adjunct to Levodopa Ups Daily ON Time in Parkinson Disease

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Significant reduction also seen in change from baseline in daily OFF times versus placebo

Alteplase Increases Frequency of Functional Independence After Posterior Circulation Stroke

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Findings seen in patients with posterior circulation stroke and with no planned thrombectomy who received alteplase 4.5 to 24 hours after stroke onset

Prevalence of Prescription Stimulant Misuse High in U.S. Adults

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Higher prevalence ratios for misuse, prescription stimulant use disorder seen for those using amphetamines versus methylphenidate

FDA Approves Cabozantinib for Previously Treated Advanced Neuroendocrine Tumors

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Patients treated with cabozantinib survived significantly longer with no worsening of their disease compared with patients who received placebo

Pelabresib Plus Ruxolitinib Improves Underlying Myelofibrosis

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In a recent study, significantly more patients receiving the combination therapy met primary end point of reduction in spleen volume of ≥35 percent from baseline

Heart Failure Patients With Ejection Fraction Improvement Rarely Withdrawn From Meds

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Withdrawing renin-angiotensin inhibitors/angiotensin receptor-neprilysin inhibitors and mineralocorticoid receptor antagonists tied to higher one-year mortality, morbidity

Molecular Residual Disease Analysis May Predict Disease Recurrence After Lung Cancer Resection

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Molecular residual disease precedes DFS events in patients receiving osimertinib, placebo; most events occur after osimertinib discontinuation or completion

Long-Term Gantenerumab May Slow Decline in Dominantly Inherited Alzheimer Disease

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Hazard ratio for clinical decline in Clinical Dementia Rating-Sum of Boxes was 0.53 for those treated with gantenerumab the longest

FDA Approves Blujepa for Uncomplicated Urinary Tract Infections

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Medication approved for uUTIs in women and pediatric patients aged 12 years and older

Tenecteplase Is Reasonable Alternative to Alteplase for Ischemic Stroke

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No significant difference seen in terms of effectiveness or safety outcomes, including functional independence at discharge