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Treatment Effect of Tofacitinib, Adalimumab Compared in RA

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Modest reduction seen in DAS28-CPR at three months for those receiving TOF versus ADA, but no difference seen at nine months

Pharmacy-Level Stewardship Can Save on Immune Checkpoint Inhibitors

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Strategies include dose rounding and vial sharing, as well as weight-based dosing

European Regulators Investigating Risk for Suicidal Thoughts With Popular Weight-Loss Drugs

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Three case reports from Iceland spurred the review; two of the cases involved Ozempic

Stimulant Treatment for Childhood ADHD Not Linked to Substance Use

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No evidence seen for link between childhood stimulant treatment and substance use during adolescence and young adulthood

Variation Seen in Dosing of Meds at Prehospital Pediatric Encounters

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Lowest consistency with guidelines was seen for diazepam and lorazepam; most deviations represented an underdose

P2Y₁₂ Inhibitor Monotherapy Better Than Aspirin in Coronary Artery Disease

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Reduced risk seen for composite of cardiovascular death, myocardial infarction, and stroke

Therapeutic Value of Drugs Lower for Supplemental Versus First Indications

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For first three approved indications, second and third indication approvals less likely to have high value rating

Mirikizumab Tops Placebo for Moderately-to-Severely Active Ulcerative Colitis

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Mirikizumab more effective for inducing and maintaining clinical remission in patients with ulcerative colitis

Long-Acting ART Achieves Virologic Suppression for People With HIV

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97.5 percent were projected to achieve virologic suppression by a median of 33 weeks

Medical Cannabis Laws Seem Not to Have Affected Opioid, Nonopioid Therapy

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No impact on receipt of opioid or nonopioid pain treatment seen among patients with chronic noncancer pain