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Oral Probenecid Cuts Time to Viral Clearance in COVID-19

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Median time to viral clearance was significantly shorter for 500, 1,000 mg probenecid versus placebo

Leukemia With IKZF₁ Deletion Benefits From Prolonged Maintenance Therapy

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Prolonged maintenance therapy for IKZF₁del improved five-year cumulative risk for relapse and event-free survival

Odds of Gabapentin Rx Down for Adults With LBP Receiving Spinal Manipulation

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Reduced odds seen for receiving gabapentin prescription in adults receiving chiropractic spinal manipulative therapy

Zuranolone Beneficial for Treatment of Postpartum Depression

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Significant improvement seen in 17-item Hamilton Depression Rating Scale, Clinical Global Impressions severity score

Selinexor Increases PFS for Endometrial Cancer With TP53 Mutations

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Findings seen for maintenance therapy in patients with advanced or recurrent disease following response to systemic therapy

Review: Oral Isotretinoin Is Best Treatment for Acne

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Meta-analysis reveals triple therapies containing topical retinoid, benzoyl peroxide, and antibiotic are next best

Orexin Receptor 2 Agonist Improves Sleepiness in Narcolepsy

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Improvement seen in measures of sleepiness, cataplexy over eight weeks versus placebo, but drug was associated with hepatotoxic effects

2001 to 2020 Saw Shift in Rx for Disease-Modifying Therapy for Multiple Sclerosis

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Oral disease-modifying therapies dominated new initiations by 2020 to 62.3 percent

Voclosporin Safe, Effective for Long-Term Treatment of Lupus Nephritis

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Benefits include maintenance of urine protein creatinine ratio reductions, preserved kidney function

Maternal Labor Epidural Analgesia May Be Linked to Autism in Children

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Risk increased with labor epidural analgesia alone and labor epidural analgesia and oxytocin compared with no exposure