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Ubrogepant Beneficial for Treating Migraine During the Prodrome

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Absence of moderate or severe headache reported in 46 and 29 percent of prodrome events that had been treated with ubrogepant, placebo

Publication Bias Inflates Apparent Efficacy of Alprazolam XR

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One of five trials in the FDA review was positive; all three trials in the published literature were positive

Recommendations Developed for Atopic Dermatitis Therapies

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Guidelines include strong recommendations for monoclonal antibodies and JAK inhibitors

Gantenerumab Does Not Slow Clinical Decline in Early Alzheimer Disease

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Two trials show lower amyloid plaque burden with gantenerumab versus placebo at 116 weeks

Obinutuzumab Preserves Kidney Function in Lupus Nephritis

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Reduction seen in risk for developing composite kidney outcome

Overall Survival Benefit Up for Pyrotinib + Capecitabine in HER2-Positive Breast Cancer

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Overall survival benefit demonstrated among patients with metastatic breast cancer who had received trastuzumab and taxanes

Osimertinib + Chemo Improves Progression-Free Survival in Advanced NSCLC

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Greater incidence of grade 3 or higher adverse events from any cause seen in combination group versus monotherapy

Pembrolizumab + Standard Chemotherapy Beneficial in Mesothelioma

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Improvement in overall survival seen for patients receiving cisplatin or carboplatin with pemetrexed

Higher Visceral Adipose Tissue May Need Higher Infliximab Levels for IBD Remission

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Both visceral adipose percentage and infliximab levels independently tied to steroid-free deep remission

Estrogen-Linked Thrombotic Biomarkers Drop After Cessation of Combo Pill

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Decreases seen at week 12, with most of the decrease achieved at two and four weeks after cessation of combined hormonal contraceptives