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Addition of Durvalumab, Bevacizumab to TACE Beneficial in Liver Cancer

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Progression-free survival significantly improved in unresectable hepatocellular carcinoma versus TACE alone

Dexmedetomidine Cuts Incidence of Postpartum Depression After C-Section

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Reduction in incidence of positive PPD screening seen among women with prenatal depression undergoing elective C-section

Oral Switch Noninferior for Low-Risk S. Aureus Bloodstream Infection

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Early oral antimicrobial therapy noninferior to intravenous standard therapy for low-risk bloodstream infection

Monoclonal Antibodies Provide Small Benefits in Alzheimer Disease

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Harms include increased risks for amyloid-related imaging abnormalities (ARIA)-edema, ARIA-hemorrhage, and symptomatic ARIA-edema

Exhalation Delivery System With Fluticasone Effective for Rhinosinusitis

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EDS-FLU improved symptoms, sinus opacification, acute exacerbations in two randomized trials in adults with chronic rhinosinusitis

Meds Rarely Offered for COVID-19 Patients at High Risk for Progression

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No reason other than mild symptoms given for almost half of patients at high risk for progression who were not offered treatment

2004 to 2019 Saw Increase in Isotretinoin Use in Girls, Women

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In base case analysis, 178 pregnancies were exposed to isotretinoin, with a doubling of the number per year during the study period

Denosumab Linked to Severe Hypocalcemia in Dialysis-Dependent Seniors

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Risk increased for severe and very severe hypocalcemia for female dialysis-dependent Medicare patients aged 65 years or older

Congenital Malformation Risk Lower With Buprenorphine Versus Methadone

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Buprenorphine associated with lower risk for malformations, cardiac malformations, oral clefts, and clubfoot

2015 to 2021 Saw Increase in Gabapentinoid Use

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Authors say increase driven by off-label uses for chronic pain with lack of evidence supporting use