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The endothelin-1 blocker macitentan does not reduce the number of new digital ulcers over 16 weeks among patients with systemic sclerosis and active ischemic digital ulcers

Macitentan Doesn’t Reduce Number of New Digital Ulcers

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Findings over 16 weeks among patients with systemic sclerosis and active ischemic digital ulcers
Low doses of ketamine may quickly reduce suicidal thoughts in patients with treatment-resistant depression

Ketamine May Ease Suicidal Thoughts in Major Depression

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Small study found that the drug worked quickly in patients with treatment-resistant depression
For patients with lipodystrophy

Metreleptin Ups Resting-State Connectivity in Lipodystrophy

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Significant increases in hypothalamus; insula, superior temporal gyrus; medial prefrontal cortex
Genetic variants have been identified in psoriasis patients that correlate with anti-tumor necrosis factor-α treatment response

Genetic Variants ID Treatment Response in Psoriasis

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Ten SNPs presented that correlate with treatment responses to anti-TNF-α agents
For patients with compensated hepatitis C virus cirrhosis

Survival for HCV Cirrhosis, SVR Same As General Population

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Findings in patients with compensated HCV cirrhosis who achieve SVR on interferon-based regimen
A drug allergy passport

Drug Allergy Passport Advised for Patients With Hypersensitivity

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Patients should be advised to carry passport at all times, especially when away from home
Americans could save tens of billions of dollars with more efficient drug use

Cutting Brand-Name Drug Use Could Save U.S. $73 Billion

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The nation spends more on medications than any other country
Ticagrelor is not superior to aspirin for patients with acute ischemic stroke or transient ischemic attack

Ticagrelor Doesn’t Beat Aspirin in Ischemic Stroke, TIA

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Ticagrelor not superior to aspirin for reducing composite of stroke, myocardial infarction, death
A smartphone app might offer an alternative for certain patients with atrial fibrillation who are on chronic anticoagulation medication

Anticoagulation ‘As Needed’ May Be Safe, Effective in A-Fib

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Smartphone app may help some people with atrial fibrillation take drugs on an as-needed basis
A nasal spray may provide relief for patients struggling with nocturia

AUA: Nasal Spray Linked to Decreased Nocturia, Better QoL

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In second study, exercise also found to improve nocturia