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Hydroxyurea may help preserve lung function in children with sickle cell disease

ATS: Hydroxyurea Can Up Lung Function in Sickle Cell Disease

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Drug slowed down the annual decline children had been showing before starting treatment
Dose and duration of therapy are associated with mortality for new antipsychotic users

For New Antipsychotic Users, Dose, Duration Impact Mortality

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Lower mortality risk for modified standardized daily dose of 1 or less versus greater than 1
Hospitalists report limited success and satisfaction for management of acute exacerbations of chronic pain with opioids

Hospitalists Need Strategies for Providing Adequate Pain Relief

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Hospitalists report limited success for management of acute exacerbations of chronic pain with opioids
For patients with a history of chronic obstructive pulmonary disease exacerbations

ATS: Indacaterol-Glycopyrronium Cuts COPD Exacerbations

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More effective than salmeterol-fluticasone for patients with history of COPD exacerbations
For older adults

Fall Risk Up With Initiation, Intensification of HTN Meds

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Short-term fall risk up during 15 days after initiation, intensification of antihypertensive medication
Patients with bipolar disorder taking lithium have lower rates of self-harm and unintentional injury compared to those taking other mood stabilizers

Fewer Self-Injury Events With Lithium for Bipolar Disorder

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Patients on one of the alternative mood stabilizers were 40 percent more likely to harm themselves
For premenopausal women with breast cancer

Two Years of Tamoxifen Offers Long-Term Survival Benefit

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Survival benefit for premenopausal women with estrogen receptor-positive primary breast cancer
Nilotinib is associated with scurvy

Nilotinib Associated With Case of Scurvy

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Drug appears to affect cutaneous metabolism; patient improved with ascorbic acid supplements
The synthetic prostaglandin E1 analogue misoprostol has known severe side effects and should be considered in cases of postpartum hyperthermia

Misoprostol Should Be Considered in Postpartum Hyperthermia

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Report of 21-year-old with severe hyperthermia, rigors, tachycardia, transient encephalopathy
The endothelin-1 blocker macitentan does not reduce the number of new digital ulcers over 16 weeks among patients with systemic sclerosis and active ischemic digital ulcers

Macitentan Doesn’t Reduce Number of New Digital Ulcers

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Findings over 16 weeks among patients with systemic sclerosis and active ischemic digital ulcers