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Two new studies could pave the way to major changes in how severe cases of hemophilia are treated. Both studies were published in the May 26 issue of the New England Journal of Medicine.

New Findings Offer Hope for Those With Severe Hemophilia

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One study pinpoints when standard therapy works best; another uncovers the promise of a new drug
AMPK activation by metformin is associated with inhibition of interstitial fibrosis and suppression of transforming growth factor β-1

Metformin Combats Adipose Tissue Expansion Via AMPK

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AMPK activation is linked to inhibition of interstitial fibrosis, suppression of TGF-β1
For solid organ transplant recipients

Lip Cancer Risk Up for Some Solid Organ Transplant Recipients

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Cancer risk up with high mean daily dose of azathioprine, longer duration of immunosupression
An updated clinical guideline adds two new types of drugs to the list of treatment options for heart failure. The updated guideline was published online May 20 in the Journal of the American College of Cardiology

Two New Drugs Added to Heart Failure Clinical Practice Guideline

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Heart groups issue updated guideline for the treatment of heart failure
In a sign that the opioid epidemic might be waning

Opioid Prescriptions Drop for First Time in Two Decades

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Several health data companies report a 12 to 18 percent drop in prescriptions since 2012
Treatment with sulfonylureas (ATP-sensitive potassium [KATP] channel blockers) may inhibit the neuroprotective effects of KATP channel activation and increase the risk of stroke

Sulfonylureas May Inhibit KATP Channel Neuroprotection

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Treatment with sulfonylureas may increase the risk of stroke mortality in patients with type 2 diabetes
In patients with telomere diseases

Danazol Treatment Linked to Telomere Elongation

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Reduction in rate of telomere attrition at 24 months; gain in telomere length seen from six months
For patients undergoing transcatheter aortic valve replacement

High Rate of Cerebral Embolization During TAVR

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No significant differences in cerebral embolization measures during TAVR with bivalirudin vs. heparin
For patients receiving an everolimus-eluting stent implantation

Adverse Events Not Up With Six Months of DAPT

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Comparable results for 12-month DAPT among patients receiving everolimus-eluting stents
Use of pembrolizumab (Keytruda) in advanced melanoma is extending survival for many and even curing some

ASCO: Pembrolizumab Improves Survival in Melanoma

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Three-year overall survival rate of 40 percent; median overall survival of 24.4 months