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Improved Outcomes Seen With Ibrutinib in Chronic Lymphocytic Leukemia

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Time to next treatment was improved for first-line ibrutinib versus chemoimmunotherapy in match-adjusted analyses

Angiotensin Receptor Blocker Use Linked to Lower Incidence of Epilepsy

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Findings seen in patients with no preexisting history of stroke or cardiovascular disease in subgroup analyses

ViPOR Results in Durable Remission in Specific Subtypes of Lymphoma

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Complete responses seen in 38 percent of patients, all with non-GCB DLBCL, high-grade B-cell lymphoma with rearrangements of MYC and BCL2 or BCL6

Reteplase Superior to Alteplase Within 4.5 Hours of Ischemic Stroke

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Reteplase more likely to result in excellent functional outcome than alteplase for ischemic stroke within 4.5 hours of symptom onset

FDA Approves Augtyro for NTRK-Positive Advanced Solid Tumors

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Approval is for both TKI-naive and TKI-pretreated patients across solid tumor types

Dementia With Lewy Bodies Risk Down With α-1 Adrenergic Receptor Antagonists

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Risk for developing DLB was lower for men newly started on Tz/Dz/Az compared with those taking tamsulosin or 5ARI

Trametinib Safe, Effective for Juvenile Myelomonocytic Leukemia

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Seven of 10 children with relapsed or refractory JMML completed all 12 cycles of therapy or used trametinib as bridge to HSCT

Lebrikizumab Tied to Sustained Atopic Dermatitis Treatment Effect

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Findings seen despite negligible remaining lebrikizumab serum concentrations following treatment withdrawal

Continuing Metformin in Pregnancy Has Little Effect on Nonlive Birth

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Little to no increased risk for nonlive birth seen among women continuing metformin and adding insulin versus switching to insulin monotherapy

Paternal Metformin Use Not Linked to Major Congenital Malformations

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No significant association seen for increased risk for MCMs with metformin in monotherapy, but association suggested for metformin in polytherapy