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Despite initial concern from early studies

Lamotrigine in Pregnancy Not Linked to Certain Birth Defects

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Excess risk of orofacial cleft estimated to be less than one in every 550 exposed babies
For patients with worsening heart failure

Diuretic Dose Not Linked to Outcome in Heart Failure

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In multivariate analysis, no correlation seen for patients with worsening heart failure
For patients with primary hyperparathyroidism

Surgery Cuts Fracture Risk in Primary Hyperparathyroidism

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Reduced fracture risk for surgery; bisphosphonate treatment no better than observation
Expert consensus guidance has been issued regarding the use of non-statin therapies to lower cholesterol in high-risk patients. The consensus document was published online April 1 in the Journal of the American College of Cardiology to coincide with presentation at the annual meeting of the American College of Cardiology

ACC: Expert Guidance Issued for Use of Non-Statin Therapies

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Authors recommend addition of ezetimibe at 10 mg/day for higher-risk patients
Diabetes medications containing saxagliptin and alogliptin may raise the risk of heart failure

FDA Issues New Warning for Two Diabetes Medications

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Drugs containing saxagliptin or alogliptin may be linked to heart failure risk
Hydromorphone may be another treatment option for heroin addiction

Hydromorphone May Be New Treatment for Heroin Addiction

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Researchers find hydromorphone an effective, widely available, licensed choice
Early intravenous metoprolol before primary percutaneous coronary intervention does not reduce infarct size in a population with ST-segment elevation myocardial infarction

ACC: Pre-pPCI Metoprolol Doesn’t Reduce Infarct Size in STEMI

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Metoprolol cut incidence of malignant arrhythmias; was not linked to increase in adverse events
For patients with acute myocardial infarction

ACC: Losmapimod Doesn’t Cut Cardio Events After Acute MI

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In part A of trial, no reduction in risk of composite of cardiovascular death, MI, severe recurrent ischemia
For children aged 4 to 18 years

Child Mental Health Care Varies Widely in Primary Care Settings

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Prevalence of mental health diagnosis, psychotropic medication prescribing vary across U.S. practices
For patients with Parkinson's disease admitted to the hospital

Under-Dosing Worsens Prognosis for PD Patients With Infection

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Findings among patients with Parkinson's disease admitted to the hospital with pneumonia, UTI