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Lisinopril therapy is associated with a significant reduction in incident conduction system disease

Lisinopril Therapy Cuts Incident Conduction System Disease

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Factors independently associated with disease include increased age, male sex, white race, diabetes
The experimental drug midostaurin may reverse organ damage in patients with advanced systemic mastocytosis

Midostaurin Beneficial in Advanced Systemic Mastocytosis

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Organ damage improved in 60 percent of patients with advanced systemic mastocytosis
Certain cancer immunotherapy drugs may increase risk for rheumatic disease

Cancer Immunotherapy May Induce Arthritis, Sicca Syndrome

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Findings with ipilimumab (anti-CTLA-4) and/or nivolumab (anti-PD-1) for solid tumors
In older adults

Depression Cuts Adherence to COPD Maintenance Meds

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Average monthly adherence to COPD maintenance medications low in older adults
Pharmacy programs to reduce opioid abuse are effective but underused

Pharmacy Programs to ID Opioid Abuse Effective, but Underused

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Monitoring program in Maine was only used by 56 percent of pharmacists
For patients with minor ischemic stroke or transient ischemic attack

Clopidogrel Plus Aspirin Good for Noncarriers of CYP2C19 Variants

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Reduction in risk of new stroke for clopidogrel plus aspirin in those not carrying loss-of-function alleles
Patients on long-term opioid therapy who receive prescriptions for naloxone are less likely to return for emergency care related to opioid use

Coprescribing Naloxone to Opioid Users Helps Reduce ER Visits

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Finding supports naloxone prescriptions for patients taking opioids for chronic pain
Methylene blue may increase activity in brain regions involved in short-term memory and attention
For patients with type 2 diabetes taking metformin

Liraglutide Tops Lixisenatide As Add-On to Metformin in T2DM

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Greater reduction in hemoglobin A1c, greater reduction in fasting plasma glucose with liraglutide
In patients with early breast cancer

Candesartan Doesn’t Prevent Trastuzumab Cardiotoxicity

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Cumulative incidence of cardiac events not significantly different with candesartan, placebo