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The magnitude of the risk of adverse outcomes associated with metamizole use varies in different studies

Variation in Risk of Adverse Outcomes With Metamizole

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Relative risk estimates vary from 1.5 to 40.2 for agranulocytosis, from 1.5 to 2.7 for upper GI bleed
Deprescribing of antipsychotics in long-term care residents with previous behavioral and psychological symptoms of dementia is feasible

AAIC: Deprescribing Antipsychotics Feasible in Elderly

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Staff training can help eliminate inappropriate practices in nursing homes, study says
Among veterans

Meds Up Hospitalization for Dehydration, Heat-Linked Illness

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Commonly used meds linked to increased risk of hospitalization for dehydration, heat-related illness
Total drug expenditures are expected to increase by 11 to 13 percent in 2016

Total Drug Expenditures Projected to Increase in 2016

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In nonfederal hospitals, growth in spending mainly due to increased prices for existing drugs
Persistent use of antihypertensive treatments is greater with the new generation of beta-blockers

Persistent Use Higher With New Generation Beta-Blockers

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Notable improvement seen with carvedilol and nebivolol, but not betaxolol
Among adult patients discharged from state psychiatric inpatient hospitals

Antipsychotic Polypharmacy Has Prevalence of 12 Percent

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Diagnosis of schizophrenia, length of stay of 90 days or more are strongest predictors of polypharmacy
For patients with moderate to severe diabetic peripheral neuropathic pain

Buprenorphine May Be Helpful in Peripheral Neuropathic Pain

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When tolerated, buprenorphine is effective for DPNP, but many patients withdrew from study
An experimental drug spurred substantial weight loss in patients with proopiomelanocortin deficiency

Drug Shows Promise for Genetic Proopiomelanocortin Deficiency

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After 10 months of daily treatment, one patient lost 112 lbs; another lost 45 lbs in three months
There are no significant differences in the associations between available glucose-lowering drugs (alone or in combination) and the risk of cardiovascular or all-cause mortality

Diabetes Meds Deemed Equal, but Metformin Still First-Line

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No significant differences in risk of cardiovascular or all-cause mortality
For pediatric patients

Biologic Response Modifier Use in Kids Ups Infectious Complications

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Risk varies with class of BRM; increased risk of mycobacterial, viral, fungal, opportunistic infections