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The growth differentiation factor 15 is a novel biomarker for the use and dosing of metformin

Serum Biomarker That Reflects Use, Dose of Metformin Identified

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Finding may provide clues about metformin's mechanism of action and effect
The novel herpes simplex virus (HSV) helicase-primase inhibitor pritelivir is more effective than valacyclovir for reducing genital HSV-2 shedding

Pritelivir Beats Valacyclovir for Genital HSV-2 Shedding

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Phase 2 trial shows decline in relative risk of herpes simplex virus shedding over 28 days
A two-way

Daily Text Messaging Ups ART Adherence in Youth

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Personalized daily text messaging improves adherence over six-month intervention
For patients with type 2 diabetes

Lowest Glucose Variability for Insulin + GLP-1 RA in T2DM

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Lowest glucose variability, hypoglycemia for basal insulin + GLP-1 receptor agonist regimen
For patients with type 2 diabetes mellitus

Long-Term DPP4-Inhibitor Use Not Tied to Fracture Risk in T2DM

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No increase in risk of any fracture, osteoporotic or hip fractures with continuous long-term use
The Drug Enforcement Administration has announced critical changes in its registration renewal process

DEA Announces Critical Changes in Registration Renewal Process

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The ability to renew a registration online after the expiration date will no longer be available
For superficial or nodular basal cell carcinoma at low-risk sites

Imiquimod Has Sustained Benefit for Basal Cell Carcinoma

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Lower treatment success for imiquimod 5 percent than surgery, but rates similar at three, five years
The prices of brand-name drugs used by many older Americans rose nearly 130 times faster than inflation last year

AARP: Medication Costs for Seniors Continue to Soar

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Cost of brand-name drugs for chronic conditions rose nearly 130 times faster than inflation rate
Outcomes-based pricing for novel and expensive biopharmaceuticals is supported in an Ideas and Opinions piece published online Dec. 13 in the Annals of Internal Medicine.

Outcomes-Based Pricing Suggested for New, Costly Drugs

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Strategy would compel manufacturers and insurers to share accountability for clinical outcomes
β-blockers may not be the medicine of choice for nursing home residents with dementia

β-Blockers May Not Be Appropriate for Dementia Patients

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In this group, use of drugs after acute myocardial infarction can compromise quality of life