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The oral selective inhibitor of MAPK kinase 1 and 2

Selumetinib Active in Children With Neurofibromatosis Type 1

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Patients were able to receive selumetinib on long-term basis; maximum tolerated dose 25 mg/m²
Ustekinumab is tolerated for treatment of atopic dermatitis in certain patients

Ustekinumab Tolerated in Severe Atopic Dermatitis

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Four of 10 patients show response to treatment, with one patient experiencing complete response
Good outcome has been reported in a pregnant woman who continued ustekinumab therapy for Crohn's disease during pregnancy

Case Report: Ustekinumab for Crohn’s Continued in Pregnancy

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Patient receiving UST maintenance therapy had uneventful pregnancy, delivered healthy baby
The recombinant growth factor

Phase I Trial Shows Promise for Cimaglermin in Heart Failure

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First-in-human trial shows cimaglermin generally well tolerated in left ventricular systolic dysfunction
There is high satisfaction for a postpartum self-administered medication program on postpartum wards

Most Postpartum Moms OK With Self-Administered Pain Meds

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Eighty percent median overall improvement in pain; some users would prefer drug dispensing by nurse
A direct referral program and use of an interim buprenorphine regimen can be beneficial for encouraging individuals with an opioid-use disorder to seek help

Police Referral Without Arrest Lets Opioid Abusers Seek Help

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And, interim buprenorphine regime can reduce drug-related risks while waiting for opioid abuse tx
For patients with Parkinson's disease receiving levodopa therapy and experiencing end-of-dose motor fluctuations

Opicapone As Levodopa Adjunct Cuts Motor Fluctuations in PD

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In Parkinson's disease, 50-mg/day opicapone linked to significant reduction in mean daily off-time
The association between medication regimen complexity and either treatment nonadherence or hospitalization in elderly patients remains unclear

Impact of Complex Medication Regimen in Elderly Unclear

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Mixed evidence found between regimen complexity and nonadherence, hospitalization
Studies reporting pharmacological and adjuvant analgesic modalities for post-craniotomy pain control have significant divergence in their research methods

Research for Post-Craniotomy Analgesia Uneven in Quality

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Finding of superior pain relief with opioids, with no significant side effects, but study quality deemed low
Ocrelizumab

Ocrelizumab Targets Role of B Cells in Multiple Sclerosis

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Studies show lower relapse rate in relapsing MS, lower rate of progression in primary progressive dz