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From 2000 to 2011 there were shifts in the treatment of advanced-stage non-small-cell lung cancer

2000 to 2011 Saw Shift in Treatment for Advanced NSCLC

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Rise in use of pemetrexed, erlotinib, bevacizumab; longest treatment duration with these agents
For high-risk women

Letrozole Tops Aspirin for Halting Ovarian Hyperstimulation

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Decreases incidence of moderate and severe early-onset ovarian hyperstimulation syndrome
After metformin failure

Sequential Empagliflozin, Linagliptin Diabetes Tx Effective

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Glucose control most probably mediated by effects on alpha- and beta-cell function
Fenofibrate therapy may reduce cardiovascular disease in statin-treated patients with diabetes and dyslipidemia

Fenofibrate May Reduce CVD in Patients With DM, Dyslipidemia

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No reduction in primary outcome for 4,644 ACCORD participants followed for median of 9.7 years
For patients with chronic kidney disease

Metformin Tied to Better Clinical Outcomes in CKD, CHF, CLD

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Reduced all-cause death for chronic kidney disease, congestive heart failure, chronic liver disease
The American College of Physicians has updated recommendations on the oral pharmacologic treatment of type 2 diabetes in adults. The clinical practice guideline update was published online Jan. 3 in the Annals of Internal Medicine.

ACP Updates Recommendations for Oral Medications in T2DM

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Recs serve as update to 2012 American College of Physicians guideline
Use of zoledronic acid every 12 weeks does not result in increased risk of skeletal events compared with use every four weeks among patients with bone metastases due to breast cancer

Zoledronic Acid Every 12 Weeks Noninferior in Bone Metastases

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No increase in risk of skeletal events versus treatment every four weeks for bone metastases
For adolescents with chronic hepatitis C virus genotype 1 infection

Ledipasvir-Sofosbuvir Effective for Chronic HCV in Adolescents

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98 of 100 patients reached sustained virologic response at 12 weeks; no virologic failure observed
Anticholinergic medications are frequently prescribed to older adults

Burden of Anticholinergic Meds in Older Adults Must Be Considered

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Often prescribed to older adults; measures developed for quantifying anticholinergic burden
For eyes experiencing substantial visual loss after macular laser photocoagulation treatment for diabetic macular edema

Aflibercept Rescues Vision After Laser for Diabetic Macular Edema

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Improves visual and anatomic outcomes among eyes experiencing visual loss after laser DME treatment